Literature DB >> 17502846

Two new non-competitive mGlu1 receptor antagonists are potent tools to unravel functions of this mGlu receptor subtype.

T Knöpfel1.   

Abstract

The validation of the selective, potent and systemically active non-competitive mGlu1 antagonists YM-298198 and JNJ16259685 in a physiological functional assay will facilitate elucidation of this receptor's role in brain function and as a potential drug target.

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Year:  2007        PMID： 17502846      PMCID： PMC2014133          DOI： 10.1038/sj.bjp.0707289

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  16 in total

Review 1.  Metabotropic glutamate receptors: electrical and chemical signaling properties.

Authors:  Victoria Coutinho; Thomas Knöpfel
Journal:  Neuroscientist       Date:  2002-12       Impact factor: 7.519

2.  Potent and specific action of the mGlu1 antagonists YM-298198 and JNJ16259685 on synaptic transmission in rat cerebellar slices.

Authors:  I Fukunaga; C H Yeo; A M Batchelor
Journal:  Br J Pharmacol       Date:  2007-05-14       Impact factor: 8.739

3.  Sequence and expression of a metabotropic glutamate receptor.

Authors:  M Masu; Y Tanabe; K Tsuchida; R Shigemoto; S Nakanishi
Journal:  Nature       Date:  1991-02-28       Impact factor: 49.962

4.  Expression and coupling to polyphosphoinositide hydrolysis of group I metabotropic glutamate receptors in early postnatal and adult rat brain.

Authors:  G Casabona; T Knöpfel; R Kuhn; F Gasparini; P Baumann; M A Sortino; A Copani; F Nicoletti
Journal:  Eur J Neurosci       Date:  1997-01       Impact factor: 3.386

5.  Synaptic activation of metabotropic glutamate receptors in the parallel fibre-Purkinje cell pathway in rat cerebellar slices.

Authors:  A M Batchelor; D J Madge; J Garthwaite
Journal:  Neuroscience       Date:  1994-12       Impact factor: 3.590

6.  The mGlu1 antagonist CPCCOEt enhances the climbing fibre response in Purkinje neurones independently of glutamate receptors.

Authors:  Izumi Fukunaga; Christopher H Yeo; Andrew M Batchelor
Journal:  Neuropharmacology       Date:  2006-10-10       Impact factor: 5.250

Review 7.  Metabotropic glutamate receptors: novel targets for drug development.

Authors:  T Knöpfel; R Kuhn; H Allgeier
Journal:  J Med Chem       Date:  1995-04-28       Impact factor: 7.446

8.  Potassium conductances in hippocampal neurons blocked by excitatory amino-acid transmitters.

Authors:  S Charpak; B H Gähwiler; K Q Do; T Knöpfel
Journal:  Nature       Date:  1990-10-25       Impact factor: 49.962

9.  Effects of mGlu1 receptor blockade on anxiety-related behaviour in the rat lick suppression test.

Authors:  Thomas Steckler; Hilde Lavreysen; Ana M Oliveira; Nancy Aerts; Hansfried Van Craenendonck; Jos Prickaerts; Anton Megens; Anne S J Lesage
Journal:  Psychopharmacology (Berl)       Date:  2004-12-04       Impact factor: 4.530

Review 10.  Metabotropic glutamate receptors: a new target for the therapy of neurodegenerative disorders?

Authors:  F Nicoletti; V Bruno; A Copani; G Casabona; T Knöpfel
Journal:  Trends Neurosci       Date:  1996-07       Impact factor: 13.837
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  4 in total

1.  Novel mGluR- and CB1R-independent suppression of GABA release caused by a contaminant of the group I metabotropic glutamate receptor agonist, DHPG.

Authors:  Carlos A Lafourcade; Longhua Zhang; Bradley E Alger
Journal:  PLoS One       Date:  2009-07-01       Impact factor: 3.240

Review 2.  Rebound discharge in deep cerebellar nuclear neurons in vitro.

Authors:  Reza Tadayonnejad; Dustin Anderson; Michael L Molineux; W Hamish Mehaffey; Kusala Jayasuriya; Ray W Turner
Journal:  Cerebellum       Date:  2010-09       Impact factor: 3.847

3.  Separate Ionotropic and Metabotropic Glutamate Receptor Functions in Depotentiation vs. LTP: A Distinct Role for Group1 mGluR Subtypes and NMDARs.

Authors:  Amira Latif-Hernandez; Enrico Faldini; Tariq Ahmed; Detlef Balschun
Journal:  Front Cell Neurosci       Date:  2016-11-07       Impact factor: 5.505

Review 4.  Thiazolo[3,2-a]benzimidazoles: synthetic strategies, chemical transformations and biological activities.

Authors:  Khalid A Al-Rashood; Hatem A Abdel-Aziz
Journal:  Molecules       Date:  2010-05-26       Impact factor: 4.411
  4 in total

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