Literature DB >> 1847995

Sequence and expression of a metabotropic glutamate receptor.

M Masu1, Y Tanabe, K Tsuchida, R Shigemoto, S Nakanishi.   

Abstract

The complementary DNA of a metabotropic glutamate receptor coupled to inositol phosphate/Ca2+ signal transduction has been cloned and characterized. This receptor shows no sequence similarity to conventional G protein-coupled receptors and has a unique structure with large hydrophilic sequences at both sides of seven putative membrane-spanning domains. Abundant expression of this messenger RNA is observed in neuronal cells in hippocampal dentate gyrus and CA2-3 and in cerebellar Purkinje cells, suggesting the importance of this receptor in specific hippocampal and cerebellar functions.

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Year:  1991        PMID： 1847995     DOI： 10.1038/349760a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  182 in total

1.  Involvement of unique leucine-zipper motif of PSD-Zip45 (Homer 1c/vesl-1L) in group 1 metabotropic glutamate receptor clustering.

Authors:  S Tadokoro; T Tachibana; T Imanaka; W Nishida; K Sobue
Journal:  Proc Natl Acad Sci U S A       Date:  1999-11-23       Impact factor: 11.205

2.  Critical period for activity-dependent synapse elimination in developing cerebellum.

Authors:  S Kakizawa; M Yamasaki; M Watanabe; M Kano
Journal:  J Neurosci       Date:  2000-07-01       Impact factor: 6.167

3.  Agonist- and reflex-evoked internalization of metabotropic glutamate receptor 5 in enteric neurons.

Authors:  M Liu; A L Kirchgessner
Journal:  J Neurosci       Date:  2000-05-01       Impact factor: 6.167

4.  Ca(2+)-evoked serotonin secretion by parafollicular cells: roles in signal transduction of phosphatidylinositol 3'-kinase, and the gamma and zeta isoforms of protein kinase C.

Authors:  K Liu; S Hsiung; M Adlersberg; T Sacktor; M D Gershon; H Tamir
Journal:  J Neurosci       Date:  2000-02-15       Impact factor: 6.167

5.  A hebbian form of long-term potentiation dependent on mGluR1a in hippocampal inhibitory interneurons.

Authors:  Y Perez; F Morin; J C Lacaille
Journal:  Proc Natl Acad Sci U S A       Date:  2001-07-10       Impact factor: 11.205

Review 6.  The Venus flytrap of periplasmic binding proteins: an ancient protein module present in multiple drug receptors.

Authors:  C B Felder; R C Graul; A Y Lee; H P Merkle; W Sadee
Journal:  AAPS PharmSci       Date:  1999

7.  Structural views of the ligand-binding cores of a metabotropic glutamate receptor complexed with an antagonist and both glutamate and Gd3+.

Authors:  Daisuke Tsuchiya; Naoki Kunishima; Narutoshi Kamiya; Hisato Jingami; Kosuke Morikawa
Journal:  Proc Natl Acad Sci U S A       Date:  2002-02-26       Impact factor: 11.205

8.  Alternative splicing unmasks dendritic and axonal targeting signals in metabotropic glutamate receptor 1.

Authors:  Anna Francesconi; Robert M Duvoisin
Journal:  J Neurosci       Date:  2002-03-15       Impact factor: 6.167

9.  Positive allosteric modulators of metabotropic glutamate 1 receptor: characterization, mechanism of action, and binding site.

Authors:  F Knoflach; V Mutel; S Jolidon; J N Kew; P Malherbe; E Vieira; J Wichmann; J A Kemp
Journal:  Proc Natl Acad Sci U S A       Date:  2001-10-23       Impact factor: 11.205

10.  Developmental regulation of hippocampal excitatory synaptic transmission by metabotropic glutamate receptors.

Authors:  F M Ross; J Cassidy; M Wilson; S N Davies
Journal:  Br J Pharmacol       Date:  2000-10       Impact factor: 8.739
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