Literature DB >> 17494753

Darwin's greatest discovery: design without designer.

Francisco J Ayala1.   

Abstract

Darwin's greatest contribution to science is that he completed the Copernican Revolution by drawing out for biology the notion of nature as a system of matter in motion governed by natural laws. With Darwin's discovery of natural selection, the origin and adaptations of organisms were brought into the realm of science. The adaptive features of organisms could now be explained, like the phenomena of the inanimate world, as the result of natural processes, without recourse to an Intelligent Designer. The Copernican and the Darwinian Revolutions may be seen as the two stages of the one Scientific Revolution. They jointly ushered in the beginning of science in the modern sense of the word: explanation through natural laws. Darwin's theory of natural selection accounts for the "design" of organisms, and for their wondrous diversity, as the result of natural processes, the gradual accumulation of spontaneously arisen variations (mutations) sorted out by natural selection. Which characteristics will be selected depends on which variations happen to be present at a given time in a given place. This in turn depends on the random process of mutation as well as on the previous history of the organisms. Mutation and selection have jointly driven the marvelous process that, starting from microscopic organisms, has yielded orchids, birds, and humans. The theory of evolution conveys chance and necessity, randomness and determinism, jointly enmeshed in the stuff of life. This was Darwin's fundamental discovery, that there is a process that is creative, although not conscious.

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Year:  2007        PMID: 17494753      PMCID: PMC1876431          DOI: 10.1073/pnas.0701072104

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN: 0027-8424            Impact factor:   11.205


  2 in total

1.  Independent origins and rapid evolution of the placenta in the fish genus Poeciliopsis.

Authors:  David N Reznick; Mariana Mateos; Mark S Springer
Journal:  Science       Date:  2002-11-01       Impact factor: 47.728

2.  The genetic basis of adaptive melanism in pocket mice.

Authors:  Michael W Nachman; Hopi E Hoekstra; Susan L D'Agostino
Journal:  Proc Natl Acad Sci U S A       Date:  2003-04-18       Impact factor: 11.205

  2 in total
  16 in total

1.  Colloquium paper: footprints of nonsentient design inside the human genome.

Authors:  John C Avise
Journal:  Proc Natl Acad Sci U S A       Date:  2010-05-05       Impact factor: 11.205

2.  The new mutation theory of phenotypic evolution.

Authors:  Masatoshi Nei
Journal:  Proc Natl Acad Sci U S A       Date:  2007-07-17       Impact factor: 11.205

3.  Between "design" and "bricolage": genetic networks, levels of selection, and adaptive evolution.

Authors:  Adam S Wilkins
Journal:  Proc Natl Acad Sci U S A       Date:  2007-05-09       Impact factor: 11.205

4.  From the Academy: Colloquium Perspective: In the light of evolution I: Adaptation and complex design.

Authors:  John C Avise; Francisco J Ayala
Journal:  Proc Natl Acad Sci U S A       Date:  2007-05-09       Impact factor: 11.205

5.  Charles Darwin's Origin of Species, directional selection, and the evolutionary sciences today.

Authors:  Ulrich Kutschera
Journal:  Naturwissenschaften       Date:  2009-09-16

Review 6.  On the sequence-directed nature of human gene mutation: the role of genomic architecture and the local DNA sequence environment in mediating gene mutations underlying human inherited disease.

Authors:  David N Cooper; Albino Bacolla; Claude Férec; Karen M Vasquez; Hildegard Kehrer-Sawatzki; Jian-Min Chen
Journal:  Hum Mutat       Date:  2011-09-02       Impact factor: 4.878

7.  Theory of the origin, evolution, and nature of life.

Authors:  Erik D Andrulis
Journal:  Life (Basel)       Date:  2011-12-23

Review 8.  Functions of crystallins in and out of lens: roles in elongated and post-mitotic cells.

Authors:  Christine Slingsby; Graeme J Wistow
Journal:  Prog Biophys Mol Biol       Date:  2014-02-28       Impact factor: 3.667

9.  The underlying molecular and network level mechanisms in the evolution of robustness in gene regulatory networks.

Authors:  Mario Pujato; Thomas MacCarthy; Andras Fiser; Aviv Bergman
Journal:  PLoS Comput Biol       Date:  2013-01-03       Impact factor: 4.475

10.  A Unifying Mathematical Framework for Genetic Robustness, Environmental Robustness, Network Robustness and their Trade-offs on Phenotype Robustness in Biological Networks. Part III: Synthetic Gene Networks in Synthetic Biology.

Authors:  Bor-Sen Chen; Ying-Po Lin
Journal:  Evol Bioinform Online       Date:  2013-02-26       Impact factor: 1.625

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