Literature DB >> 25382118

Theory of the origin, evolution, and nature of life.

Erik D Andrulis1.   

Abstract

Life is an inordinately complex unsolved puzzle. Despite significant theoretical progress, experimental anomalies, paradoxes, and enigmas have revealed paradigmatic limitations. Thus, the advancement of scientific understanding requires new models that resolve fundamental problems. Here, I present a theoretical framework that economically fits evidence accumulated from examinations of life. This theory is based upon a straightforward and non-mathematical core model and proposes unique yet empirically consistent explanations for major phenomena including, but not limited to, quantum gravity, phase transitions of water, why living systems are predominantly CHNOPS (carbon, hydrogen, nitrogen, oxygen, phosphorus, and sulfur), homochirality of sugars and amino acids, homeoviscous adaptation, triplet code, and DNA mutations. The theoretical framework unifies the macrocosmic and microcosmic realms, validates predicted laws of nature, and solves the puzzle of the origin and evolution of cellular life in the universe.

Entities:  

Year:  2011        PMID: 25382118      PMCID: PMC4187144          DOI: 10.3390/life2010001

Source DB:  PubMed          Journal:  Life (Basel)        ISSN: 2075-1729


  568 in total

1.  Cotranscriptionally formed DNA:RNA hybrids mediate transcription elongation impairment and transcription-associated recombination.

Authors:  Pablo Huertas; Andrés Aguilera
Journal:  Mol Cell       Date:  2003-09       Impact factor: 17.970

Review 2.  Models for biological phosphoryl transfer.

Authors:  Nicholas H Williams
Journal:  Biochim Biophys Acta       Date:  2004-03-11

Review 3.  The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics.

Authors:  Jon O Lundberg; Eddie Weitzberg; Mark T Gladwin
Journal:  Nat Rev Drug Discov       Date:  2008-02       Impact factor: 84.694

Review 4.  Autoregulation of eukaryotic transcription factors.

Authors:  E Bateman
Journal:  Prog Nucleic Acid Res Mol Biol       Date:  1998

5.  Crystal structure of the nucleosome core particle at 2.8 A resolution.

Authors:  K Luger; A W Mäder; R K Richmond; D F Sargent; T J Richmond
Journal:  Nature       Date:  1997-09-18       Impact factor: 49.962

Review 6.  The eight human "canonical" ribonucleases: molecular diversity, catalytic properties, and special biological actions of the enzyme proteins.

Authors:  Salvatore Sorrentino
Journal:  FEBS Lett       Date:  2010-04-11       Impact factor: 4.124

7.  RNA-dependent DNA polymerase in virions of Rous sarcoma virus.

Authors:  H M Temin; S Mizutani
Journal:  Nature       Date:  1970-06-27       Impact factor: 49.962

8.  Spiral growth of the laminar shell of the brachiopod Crania.

Authors:  A Williams
Journal:  Calcif Tissue Res       Date:  1970

Review 9.  Quantum microbiology.

Authors:  J T Trevors; L Masson
Journal:  Curr Issues Mol Biol       Date:  2011-03-02       Impact factor: 2.081

Review 10.  Triglyceride containing lipid droplets and lipid droplet-associated proteins.

Authors:  Sven-Olof Olofsson; Pontus Boström; Linda Andersson; Mikael Rutberg; Malin Levin; Jeanna Perman; Jan Borén
Journal:  Curr Opin Lipidol       Date:  2008-10       Impact factor: 4.776

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  1 in total

1.  The ribonuclease Dis3 is an essential regulator of the developmental transcriptome.

Authors:  Dezhi Hou; Miriam Ruiz; Erik D Andrulis
Journal:  BMC Genomics       Date:  2012-08-01       Impact factor: 3.969

  1 in total

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