| Literature DB >> 16873055 |
Valérie Lallemand-Breitenbach1, Hugues de Thé.
Abstract
The PML protein induces senescence, and, upon oncogenic stress, its absence promotes cellular transformation. In this issue of Cell, Scaglioni et al. (2006) show that phosphorylation of PML by CK2, a kinase frequently activated in human cancers, promotes PML degradation. Therefore, pharmacological inhibition of CK2-induced PML loss could be used to offset tumor establishment.Entities:
Mesh：
Substances：
Year: 2006 PMID： 16873055 DOI： 10.1016/j.cell.2006.07.004
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582