Literature DB >> 17470659

Binding of ceftobiprole and comparators to the penicillin-binding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae.

Todd A Davies1, Malcolm G P Page, Wenchi Shang, Ted Andrew, Malgosia Kania, Karen Bush.   

Abstract

Ceftobiprole exhibited tight binding to PBP2a in methicillin-resistant Staphylococcus aureus, PBP2x in penicillin-resistant Streptococcus pneumoniae, and PBP3 and other essential penicillin-binding proteins in methicillin-susceptible S. aureus, Escherichia coli, and Pseudomonas aeruginosa. Ceftobiprole also bound well to PBP2 in the latter organisms, contributing to the broad-spectrum antibacterial activity against gram-negative and gram-positive bacteria.

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Year:  2007        PMID： 17470659      PMCID： PMC1913263          DOI： 10.1128/AAC.00029-07

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  28 in total

1.  In vitro evaluation of BAL9141, a novel parenteral cephalosporin active against oxacillin-resistant staphylococci.

Authors:  Ronald N Jones; Lalitagauri M Deshpande; Alan H Mutnick; Douglas J Biedenbach
Journal:  J Antimicrob Chemother       Date:  2002-12       Impact factor: 5.790

2.  Activities of ceftobiprole and other beta-lactams against Streptococcus pneumoniae clinical isolates from the United States with defined substitutions in penicillin-binding proteins PBP 1a, PBP 2b, and PBP 2x.

Authors:  Todd A Davies; Wenchi Shang; Karen Bush
Journal:  Antimicrob Agents Chemother       Date:  2006-07       Impact factor: 5.191

3.  In vitro and in vivo properties of Ro 63-9141, a novel broad-spectrum cephalosporin with activity against methicillin-resistant staphylococci.

Authors:  P Hebeisen; I Heinze-Krauss; P Angehrn; P Hohl; M G Page; R L Then
Journal:  Antimicrob Agents Chemother       Date:  2001-03       Impact factor: 5.191

4.  In vitro activities of BAL9141, a novel broad-spectrum pyrrolidinone cephalosporin, against gram-negative nonfermenters.

Authors:  R Zbinden; V Pünter; A von Graevenitz
Journal:  Antimicrob Agents Chemother       Date:  2002-03       Impact factor: 5.191

5.  Penicillin-binding protein 1A, 2B, and 2X alterations in Canadian isolates of penicillin-resistant Streptococcus pneumoniae.

Authors:  Kimberly A Nichol; George G Zhanel; Daryl J Hoban
Journal:  Antimicrob Agents Chemother       Date:  2002-10       Impact factor: 5.191

6.  Possible physiological functions of penicillin-binding proteins in Staphylococcus aureus.

Authors:  N H Georgopapadakou; B A Dix; Y R Mauriz
Journal:  Antimicrob Agents Chemother       Date:  1986-02       Impact factor: 5.191

7.  Mode of action of ceftazidime: affinity for the penicillin-binding proteins of Escherichia coli K12, Pseudomonas aeruginosa and Staphylococcus aureus.

Authors:  M V Hayes; D C Orr
Journal:  J Antimicrob Chemother       Date:  1983-08       Impact factor: 5.790

8.  Involvement of penicillin-binding protein 2 with other penicillin-binding proteins in lysis of Escherichia coli by some beta-lactam antibiotics alone and in synergistic lytic effect of amdinocillin (mecillinam).

Authors:  L Gutmann; S Vincent; D Billot-Klein; J F Acar; E Mrèna; R Williamson
Journal:  Antimicrob Agents Chemother       Date:  1986-12       Impact factor: 5.191

9.  Mode of action of azthreonam.

Authors:  N H Georgopapadakou; S A Smith; R B Sykes
Journal:  Antimicrob Agents Chemother       Date:  1982-06       Impact factor: 5.191

10.  Affinities of penicillins and cephalosporins for the penicillin-binding proteins of Escherichia coli K-12 and their antibacterial activity.

Authors:  N A Curtis; D Orr; G W Ross; M G Boulton
Journal:  Antimicrob Agents Chemother       Date:  1979-11       Impact factor: 5.191
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  53 in total

Review 1.  Molecular basis and phenotype of methicillin resistance in Staphylococcus aureus and insights into new beta-lactams that meet the challenge.

Authors:  Leticia I Llarrull; Jed F Fisher; Shahriar Mobashery
Journal:  Antimicrob Agents Chemother       Date:  2009-05-26       Impact factor: 5.191

2.  Dissection of events in the resistance to β-lactam antibiotics mediated by the protein BlaR1 from Staphylococcus aureus.

Authors:  Leticia I Llarrull; Shahriar Mobashery
Journal:  Biochemistry       Date:  2012-05-29       Impact factor: 3.162

Review 3.  Envelope Structures of Gram-Positive Bacteria.

Authors:  Mithila Rajagopal; Suzanne Walker
Journal:  Curr Top Microbiol Immunol       Date:  2017       Impact factor: 4.291

4.  In vitro selection and characterization of ceftobiprole-resistant methicillin-resistant Staphylococcus aureus.

Authors:  Ritu Banerjee; Michael Gretes; Li Basuino; Natalie Strynadka; Henry F Chambers
Journal:  Antimicrob Agents Chemother       Date:  2008-03-31       Impact factor: 5.191

5.  Effects of ceftobiprole and oxacillin on mecA expression in methicillin-resistant Staphylococcus aureus clinical isolates.

Authors:  Wenchi Shang; Todd A Davies; Robert K Flamm; Karen Bush
Journal:  Antimicrob Agents Chemother       Date:  2009-11-30       Impact factor: 5.191

6.  Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities.

Authors:  Klaudia Kosowska-Shick; Pamela McGhee; Peter C Appelbaum
Journal:  Antimicrob Agents Chemother       Date:  2009-02-23       Impact factor: 5.191

7.  Ceftobiprole activity against over 60,000 clinical bacterial pathogens isolated in Europe, Turkey, and Israel from 2005 to 2010.

Authors:  David J Farrell; Robert K Flamm; Helio S Sader; Ronald N Jones
Journal:  Antimicrob Agents Chemother       Date:  2014-04-28       Impact factor: 5.191

8.  High Rate of Ceftobiprole Resistance among Clinical Methicillin-Resistant Staphylococcus aureus Isolates from a Hospital in Central Italy.

Authors:  Gianluca Morroni; Andrea Brenciani; Lucia Brescini; Simona Fioriti; Serena Simoni; Antonella Pocognoli; Marina Mingoia; Eleonora Giovanetti; Francesco Barchiesi; Andrea Giacometti; Oscar Cirioni
Journal:  Antimicrob Agents Chemother       Date:  2018-11-26       Impact factor: 5.191

9.  Development and qualification of a pharmacodynamic model for the pronounced inoculum effect of ceftazidime against Pseudomonas aeruginosa.

Authors:  Jürgen B Bulitta; Neang S Ly; Jenny C Yang; Alan Forrest; William J Jusko; Brian T Tsuji
Journal:  Antimicrob Agents Chemother       Date:  2008-10-13       Impact factor: 5.191

10.  Modulation of cell wall structure and antimicrobial susceptibility by a Staphylococcus aureus eukaryote-like serine/threonine kinase and phosphatase.

Authors:  Amanda M Beltramini; Chitrangada D Mukhopadhyay; Vijay Pancholi
Journal:  Infect Immun       Date:  2009-02-02       Impact factor: 3.441
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