| Literature DB >> 17467575 |
Matthew N Davies1, Darren R Flower.
Abstract
Vaccine design is highly suited to the application of in silico techniques, for both the discovery and development of new and existing vaccines. Here, we discuss computational contributions to epitope mapping and reverse vaccinology, two techniques central to the new discipline of immunomics. Also discussed are methods to improve the efficiency of vaccination, such as codon optimization and adjuvant discovery in addition to the identification of allergenic proteins. We also review current software developed to facilitate vaccine design.Entities:
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Year: 2007 PMID： 17467575 DOI： 10.1016/j.drudis.2007.03.010
Source DB: PubMed Journal: Drug Discov Today ISSN： 1359-6446 Impact factor: 7.851