BACKGROUND: The diagnosis of a suspected infected prosthesis is often difficult, but is important for the choice of treatment. Even at surgery, it is not easy to assess whether the prosthesis is infected or not--even though this may be important for the choice of surgical procedure. PATIENTS AND METHODS: We assessed the sensitivity, specificity, predictive value, and reliability of the results of the analysis of frozen sections from samples of tissues taken during revision hip surgery of 136 probably infected prostheses. Samples of tissues were taken to be analyzed immediately from frozen sections, to be processed on a routine basis later, and to be referred for bacteriological cultures. A finding of 5 or more polymorphonuclear leukocytes per field at a magnification of 400x was considered positive for infection. RESULTS: The analysis of frozen sections for infection was in agreement with the results of routine histopathology in 134 of 136 cases. Comparison with the results of culture showed a sensitivity of 85%, a specificity of 87%, a PPV of 79%, an NPV of 91%, and a Kendall's tau correlation coefficient of 0.72. INTERPRETATION: We believe that the method we have tested is of value in revision surgery when infection cannot be ruled out.
BACKGROUND: The diagnosis of a suspected infected prosthesis is often difficult, but is important for the choice of treatment. Even at surgery, it is not easy to assess whether the prosthesis is infected or not--even though this may be important for the choice of surgical procedure. PATIENTS AND METHODS: We assessed the sensitivity, specificity, predictive value, and reliability of the results of the analysis of frozen sections from samples of tissues taken during revision hip surgery of 136 probably infected prostheses. Samples of tissues were taken to be analyzed immediately from frozen sections, to be processed on a routine basis later, and to be referred for bacteriological cultures. A finding of 5 or more polymorphonuclear leukocytes per field at a magnification of 400x was considered positive for infection. RESULTS: The analysis of frozen sections for infection was in agreement with the results of routine histopathology in 134 of 136 cases. Comparison with the results of culture showed a sensitivity of 85%, a specificity of 87%, a PPV of 79%, an NPV of 91%, and a Kendall's tau correlation coefficient of 0.72. INTERPRETATION: We believe that the method we have tested is of value in revision surgery when infection cannot be ruled out.
Authors: Martin A Buttaro; Diego Muñoz de la Rosa; Fernando Comba; Francisco Piccaluga Journal: Clin Orthop Relat Res Date: 2012-11 Impact factor: 4.176
Authors: Martin A Buttaro; Gabriel Martorell; Mauricio Quinteros; Fernando Comba; Gerardo Zanotti; Francisco Piccaluga Journal: Clin Orthop Relat Res Date: 2015-12 Impact factor: 4.176
Authors: Martin McNally; Ricardo Sousa; Marjan Wouthuyzen-Bakker; Antonia F Chen; Alex Soriano; H Charles Vogely; Martin Clauss; Carlos A Higuera; Rihard Trebše Journal: Bone Joint J Date: 2021-01 Impact factor: 5.082
Authors: Burak Yoldas; Deniz Cankaya; Kemal Andic; Enver Kilic; Olgun Bingol; Ali Tecirli; Ali Toprak; Yalçın Tabak Journal: Ann Med Surg (Lond) Date: 2016-07-26