Literature DB >> 17460111

Extended culture enhances sensitivity of a gamma interferon assay for latent Mycobacterium tuberculosis infection.

Ana Cehovin1, Jacqueline M Cliff, Philip C Hill, Roger H Brookes, Hazel M Dockrell.   

Abstract

To test the hypothesis that prolonged culture would enhance the sensitivity of latent tuberculosis detection by a gamma interferon release assay, blood samples from 33 household contacts of Gambian tuberculosis patients were stimulated with Mycobacterium tuberculosis-specific antigens. After 24 h of culture, 66% were positive, compared to 93% after 6 days of culture.

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Year:  2007        PMID： 17460111      PMCID： PMC1951098          DOI： 10.1128/CVI.00093-07

Source DB:  PubMed          Journal:  Clin Vaccine Immunol        ISSN： 1556-679X


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