PURPOSE: The objective of this study was to calculate tumor blood flow (TBF) in musculoskeletal lesions and to evaluate the usefulness of this parameter in differentiating malignant from benign lesions and monitoring the treatment response to preoperative chemotherapy. MATERIALS AND METHODS: Altogether, 33 patients with musculoskeletal lesions underwent a total of 50 dynamic magnetic resonance imaging (MRI) examinations, including 28 on 9 patients undergoing preoperative chemotherapy. TBF was calculated using deconvolution analysis. Steepest slope (SS) was determined from the time-intensity curve during the first pass of contrast medium. RESULTS: TBF ranged from 2.7 to 178.6 mL/100 mL/min in benign lesions and from 15.4 to 296.3 mL/100 mL/min in malignant lesions. SS ranged from 0.5%/s to 31.8%/s for benign lesions and from 3.1%/s to 64.8%/sec for malignant lesions. TBF and SS did not differ significantly between benign and malignant lesions. Among the nine patients who underwent preoperative chemotherapy, TBF after chemotherapy was lower in good responders (11.7, 11.0, 7.9 mL/100 mL/min) (n = 3, tumor necrosis > or =90%) than in poor responders (23.4-141.5 mL/100 mL/min) (n = 6, tumor necrosis <90%). CONCLUSION: TBF and SS cannot reliably differentiate malignant from benign lesions. However, they have potential utility in evaluating the preoperative treatment response in patients with malignant musculoskeletal tumors.
PURPOSE: The objective of this study was to calculate tumor blood flow (TBF) in musculoskeletal lesions and to evaluate the usefulness of this parameter in differentiating malignant from benign lesions and monitoring the treatment response to preoperative chemotherapy. MATERIALS AND METHODS: Altogether, 33 patients with musculoskeletal lesions underwent a total of 50 dynamic magnetic resonance imaging (MRI) examinations, including 28 on 9 patients undergoing preoperative chemotherapy. TBF was calculated using deconvolution analysis. Steepest slope (SS) was determined from the time-intensity curve during the first pass of contrast medium. RESULTS:TBF ranged from 2.7 to 178.6 mL/100 mL/min in benign lesions and from 15.4 to 296.3 mL/100 mL/min in malignant lesions. SS ranged from 0.5%/s to 31.8%/s for benign lesions and from 3.1%/s to 64.8%/sec for malignant lesions. TBF and SS did not differ significantly between benign and malignant lesions. Among the nine patients who underwent preoperative chemotherapy, TBF after chemotherapy was lower in good responders (11.7, 11.0, 7.9 mL/100 mL/min) (n = 3, tumor necrosis > or =90%) than in poor responders (23.4-141.5 mL/100 mL/min) (n = 6, tumor necrosis <90%). CONCLUSION:TBF and SS cannot reliably differentiate malignant from benign lesions. However, they have potential utility in evaluating the preoperative treatment response in patients with malignant musculoskeletal tumors.
Authors: R Erlemann; M F Reiser; P E Peters; P Vasallo; B Nommensen; C R Kusnierz-Glaz; J Ritter; A Roessner Journal: Radiology Date: 1989-06 Impact factor: 11.105
Authors: G Pan; A K Raymond; C H Carrasco; S Wallace; E E Kim; A Shirkhoda; N Jaffe; J A Murray; R S Benjamin Journal: Radiology Date: 1990-02 Impact factor: 11.105
Authors: Catherina S P van Rijswijk; Maartje J A Geirnaerdt; Pancras C W Hogendoorn; Johannes L Peterse; Frits van Coevorden; Antonie H M Taminiau; Rob A E M Tollenaar; Bin B R Kroon; Johan L Bloem Journal: Eur Radiol Date: 2003-01-08 Impact factor: 5.315
Authors: Jonathan P Dyke; David M Panicek; John H Healey; Paul A Meyers; Andrew G Huvos; Lawrence H Schwartz; Howard T Thaler; Paul S Tofts; Richard Gorlick; Jason A Koutcher; Douglas Ballon Journal: Radiology Date: 2003-07 Impact factor: 11.105