OBJECTIVE: To measure tumor blood flow (TBF) using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). METHODS: A DCE-MRI was performed using inversion recovery-preparation fast-field echo sequences. Dynamic data were obtained every 3.2 seconds for 2 minutes, immediately after gadolinium injection. In 14 patients with malignant musculoskeletal tumors, TBF maps were generated pixel-by-pixel by deconvolution analysis. For preclinical studies, muscle blood flow in 5 volunteers and signal intensities of different gadolinium concentrations were measured. RESULTS: There was a good linear relationship between signal intensities and gadolinium concentrations (r = 0.989, P < 0.001, at gadolinium concentrations <or=2 mmol/L). The average value of muscle blood flow in volunteers was 11.1 +/- 2.7 mL.100 mL.min. In 14 patients with musculoskeletal tumors, TBF showed wide variances: the lowest of 9.6 mL.100 mL.min in liposarcoma and the highest of 182.0 mL.100 mL.min in osteosarcoma. After chemotherapy, the TBF values (7.9, 11.0, and 11.7 mL. 100 mL.min) in the good responders were lower than those (26.8, 31.0, and 62.4 mL.100 mL.min) in the poor responders. CONCLUSIONS: A functional map of TBF generated by DCE-MRI and deconvolution analysis would be a promising tool for evaluating tumor blood flow in vivo.
OBJECTIVE: To measure tumor blood flow (TBF) using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). METHODS: A DCE-MRI was performed using inversion recovery-preparation fast-field echo sequences. Dynamic data were obtained every 3.2 seconds for 2 minutes, immediately after gadolinium injection. In 14 patients with malignant musculoskeletal tumors, TBF maps were generated pixel-by-pixel by deconvolution analysis. For preclinical studies, muscle blood flow in 5 volunteers and signal intensities of different gadolinium concentrations were measured. RESULTS: There was a good linear relationship between signal intensities and gadolinium concentrations (r = 0.989, P < 0.001, at gadolinium concentrations <or=2 mmol/L). The average value of muscle blood flow in volunteers was 11.1 +/- 2.7 mL.100 mL.min. In 14 patients with musculoskeletal tumors, TBF showed wide variances: the lowest of 9.6 mL.100 mL.min in liposarcoma and the highest of 182.0 mL.100 mL.min in osteosarcoma. After chemotherapy, the TBF values (7.9, 11.0, and 11.7 mL. 100 mL.min) in the good responders were lower than those (26.8, 31.0, and 62.4 mL.100 mL.min) in the poor responders. CONCLUSIONS: A functional map of TBF generated by DCE-MRI and deconvolution analysis would be a promising tool for evaluating tumor blood flow in vivo.
Authors: Deni Hardiansyah; Christian Maass; Ali Asgar Attarwala; Berthold Müller; Peter Kletting; Felix M Mottaghy; Gerhard Glatting Journal: Eur J Nucl Med Mol Imaging Date: 2015-11-18 Impact factor: 9.236