Literature DB >> 17449630

Structure-based functional analysis of the replication protein of plasmid R6K: key amino acids at the pi/DNA interface.

Selvi Kunnimalaiyaan1, Sheryl A Rakowski, Marcin Filutowicz.   

Abstract

In previous work, we characterized the bases in an iteron of plasmid R6K that are important for the binding of pi protein monomers and dimers. Here we investigate the following six amino acids of pi, encoded by pir, hypothesized to be important for DNA contact: Ser71, Try74, Gly131, Gly211, Arg225, and Arg254.

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Year:  2007        PMID： 17449630      PMCID： PMC1913429          DOI： 10.1128/JB.00109-07

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  20 in total

1.  Strong minor groove base conservation in sequence logos implies DNA distortion or base flipping during replication and transcription initiation.

Authors:  T D Schneider
Journal:  Nucleic Acids Res       Date:  2001-12-01       Impact factor: 16.971

2.  Binding modes of the initiator and inhibitor forms of the replication protein pi to the gamma ori iteron of plasmid R6K.

Authors:  Selvi Kunnimalaiyaan; Ricardo Krüger; Wilma Ross; Sheryl A Rakowski; Marcin Filutowicz
Journal:  J Biol Chem       Date:  2004-07-09       Impact factor: 5.157

3.  Monomer/dimer ratios of replication protein modulate the DNA strand-opening in a replication origin.

Authors:  R Krüger; I Konieczny; M Filutowicz
Journal:  J Mol Biol       Date:  2001-03-09       Impact factor: 5.469

4.  The replication initiator protein of plasmid R6K tagged with beta-galactosidase shows sequence-specific DNA-binding.

Authors:  J Germino; D Bastia
Journal:  Cell       Date:  1983-01       Impact factor: 41.582

5.  Hexahistidine (His6)-tag dependent protein dimerization: a cautionary tale.

Authors:  J Wu; M Filutowicz
Journal:  Acta Biochim Pol       Date:  1999       Impact factor: 2.149

6.  Replication of antibiotic resistance plasmid R6K DNA in vitro.

Authors:  M Inuzuka; D R Helinski
Journal:  Biochemistry       Date:  1978-06-27       Impact factor: 3.162

7.  Plasmid P1 RepA is homologous to the F plasmid RepE class of initiators.

Authors:  Suveena Sharma; Bangalore K Sathyanarayana; Jeremy G Bird; Joel R Hoskins; Byungkook Lee; Sue Wickner
Journal:  J Biol Chem       Date:  2003-11-21       Impact factor: 5.157

8.  Interaction of the plasmid R6K-encoded replication initiator protein with its binding sites on DNA.

Authors:  J Germino; D Bastia
Journal:  Cell       Date:  1983-08       Impact factor: 41.582

9.  Information analysis of sequences that bind the replication initiator RepA.

Authors:  P P Papp; D K Chattoraj; T D Schneider
Journal:  J Mol Biol       Date:  1993-09-20       Impact factor: 5.469

10.  Mutations in direct repeat sequences and in a conserved sequence adjacent to the repeats result in a defective replication origin in plasmid R6K.

Authors:  M J McEachern; M Filutowicz; D R Helinski
Journal:  Proc Natl Acad Sci U S A       Date:  1985-03       Impact factor: 11.205
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  3 in total

1.  Investigations of pi initiator protein-mediated interaction between replication origins alpha and gamma of the plasmid R6K.

Authors:  Mukesh Saxena; Samarendra Singh; Shamsu Zzaman; Deepak Bastia
Journal:  J Biol Chem       Date:  2009-12-22       Impact factor: 5.157

2.  Cooperative binding mode of the inhibitors of R6K replication, pi dimers.

Authors:  Lisa M Bowers; Marcin Filutowicz
Journal:  J Mol Biol       Date:  2008-01-26       Impact factor: 5.469

Review 3.  Plasmid R6K replication control.

Authors:  Sheryl A Rakowski; Marcin Filutowicz
Journal:  Plasmid       Date:  2013-03-05       Impact factor: 3.466
  3 in total

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