Bruce H Alexander1, Geary W Olsen. 1. Division of Environmental Health Sciences, School of Public Health, University of Minnesota, USA. balex@umn.edu
Abstract
PURPOSE: To determine whether bladder cancer is associated with exposure to perfluorooctane sulfonate (PFOS) in an occupational cohort. METHODS: Incidence of bladder cancer was ascertained by postal questionnaire to all living current and former employees of the facility (N = 1895) and death certificates for deceased workers (N = 188). Exposure to PFOS was estimated with work history records and weighted with biological monitoring data. Standardized incidence ratios (SIRs) were estimated using U.S. population-based rates as a reference. Bladder cancer risk within the cohort was evaluated using Poisson regression by cumulative PFOS exposure. RESULTS: Questionnaires were returned by 1,400 of the 1895 cohort members presumed alive. Eleven cases of primary bladder cancer were identified from the surveys (n = 6) and death certificates (n = 5). The SIRs were 1.28 (95% confidence interval [CI] = 0.64-2.29) for the entire cohort and 1.74 (95% CI = 0.64-3.79) for those ever working in a high exposed job. Compared with employees in the lowest cumulative exposure category, the relative risk of bladder cancer was 0.83 (95% CI = 0.15-4.65), 1.92 (95% CI = 0.30-12.06), and 1.52 (95% CI = 0.21-10.99). CONCLUSIONS: The results offer little support for an association between bladder cancer and PFOS exposure, but the limited size of the population prohibits a conclusive exposure response analysis.
PURPOSE: To determine whether bladder cancer is associated with exposure to perfluorooctane sulfonate (PFOS) in an occupational cohort. METHODS: Incidence of bladder cancer was ascertained by postal questionnaire to all living current and former employees of the facility (N = 1895) and death certificates for deceased workers (N = 188). Exposure to PFOS was estimated with work history records and weighted with biological monitoring data. Standardized incidence ratios (SIRs) were estimated using U.S. population-based rates as a reference. Bladder cancer risk within the cohort was evaluated using Poisson regression by cumulative PFOS exposure. RESULTS: Questionnaires were returned by 1,400 of the 1895 cohort members presumed alive. Eleven cases of primary bladder cancer were identified from the surveys (n = 6) and death certificates (n = 5). The SIRs were 1.28 (95% confidence interval [CI] = 0.64-2.29) for the entire cohort and 1.74 (95% CI = 0.64-3.79) for those ever working in a high exposed job. Compared with employees in the lowest cumulative exposure category, the relative risk of bladder cancer was 0.83 (95% CI = 0.15-4.65), 1.92 (95% CI = 0.30-12.06), and 1.52 (95% CI = 0.21-10.99). CONCLUSIONS: The results offer little support for an association between bladder cancer and PFOS exposure, but the limited size of the population prohibits a conclusive exposure response analysis.
Authors: Rachel Rogers Worley; Susan McAfee Moore; Bruce C Tierney; Xiaoyun Ye; Antonia M Calafat; Sean Campbell; Million B Woudneh; Jeffrey Fisher Journal: Environ Int Date: 2017-06-20 Impact factor: 9.621
Authors: Ana M Mora; Abby F Fleisch; Sheryl L Rifas-Shiman; Jennifer A Woo Baidal; Larissa Pardo; Thomas F Webster; Antonia M Calafat; Xiaoyun Ye; Emily Oken; Sharon K Sagiv Journal: Environ Int Date: 2017-11-20 Impact factor: 9.621