Rachel Rogers Worley1, Susan McAfee Moore2, Bruce C Tierney2, Xiaoyun Ye3, Antonia M Calafat3, Sean Campbell4, Million B Woudneh4, Jeffrey Fisher5. 1. Division of Community Health Investigations, Agency for Toxic Substances and Disease Registry, Atlanta, GA, USA. Electronic address: RWorley@cdc.gov. 2. Division of Community Health Investigations, Agency for Toxic Substances and Disease Registry, Atlanta, GA, USA. 3. Division of Laboratory Sciences, National Center for Environmental Health, Atlanta, GA, USA. 4. AXYS Analytical, Sidney, British Columbia, Canada. 5. National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR, USA.
Abstract
BACKGROUND: Per- and polyfluoroalkyl substances (PFAS) are considered chemicals of emerging concern, in part due to their environmental and biological persistence and the potential for widespread human exposure. In 2007, a PFAS manufacturer near Decatur, Alabama notified the United States Environmental Protection Agency (EPA) it had discharged PFAS into a wastewater treatment plant, resulting in environmental contamination and potential exposures to the local community. OBJECTIVES: To characterize PFAS exposure over time, the Agency for Toxic Substances and Disease Registry (ATSDR) collected blood and urine samples from local residents. METHODS: Eight PFAS were measured in serum in 2010 (n=153). Eleven PFAS were measured in serum, and five PFAS were measured in urine (n=45) from some of the same residents in 2016. Serum concentrations were compared to nationally representative data and change in serum concentration over time was evaluated. Biological half-lives were estimated for perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), and perfluorohexane sulfonic acid (PFHxS) using a one-compartment pharmacokinetic model. RESULTS: In 2010 and 2016, geometric mean PFOA and PFOS serum concentrations were elevated in participants compared to the general U.S. POPULATION: In 2016, the geometric mean PFHxS serum concentration was elevated compared to the general U.S. POPULATION: Geometric mean serum concentrations of PFOA, PFOS, and perfluorononanoic acid (PFNA) were significantly (p≤0.0001) lower (49%, 53%, and 58%, respectively) in 2016 compared to 2010. Half-lives for PFOA, PFOS, and PFHxS were estimated to be 3.9, 3.3, and 15.5years, respectively. Concentrations of PFOA in serum and urine were highly correlated (r=0.75) in males. CONCLUSIONS: Serum concentrations of some PFAS are decreasing in this residentially exposed community, but remain elevated compared to the U.S. general population. Published by Elsevier Ltd.
BACKGROUND:Per- and polyfluoroalkyl substances (PFAS) are considered chemicals of emerging concern, in part due to their environmental and biological persistence and the potential for widespread human exposure. In 2007, a PFAS manufacturer near Decatur, Alabama notified the United States Environmental Protection Agency (EPA) it had discharged PFAS into a wastewater treatment plant, resulting in environmental contamination and potential exposures to the local community. OBJECTIVES: To characterize PFAS exposure over time, the Agency for Toxic Substances and Disease Registry (ATSDR) collected blood and urine samples from local residents. METHODS: Eight PFAS were measured in serum in 2010 (n=153). Eleven PFAS were measured in serum, and five PFAS were measured in urine (n=45) from some of the same residents in 2016. Serum concentrations were compared to nationally representative data and change in serum concentration over time was evaluated. Biological half-lives were estimated for perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), and perfluorohexane sulfonic acid (PFHxS) using a one-compartment pharmacokinetic model. RESULTS: In 2010 and 2016, geometric mean PFOA and PFOS serum concentrations were elevated in participants compared to the general U.S. POPULATION: In 2016, the geometric mean PFHxS serum concentration was elevated compared to the general U.S. POPULATION: Geometric mean serum concentrations of PFOA, PFOS, and perfluorononanoic acid (PFNA) were significantly (p≤0.0001) lower (49%, 53%, and 58%, respectively) in 2016 compared to 2010. Half-lives for PFOA, PFOS, and PFHxS were estimated to be 3.9, 3.3, and 15.5years, respectively. Concentrations of PFOA in serum and urine were highly correlated (r=0.75) in males. CONCLUSIONS: Serum concentrations of some PFAS are decreasing in this residentially exposed community, but remain elevated compared to the U.S. general population. Published by Elsevier Ltd.
Authors: Christopher Lau; Julie R Thibodeaux; Roger G Hanson; Michael G Narotsky; John M Rogers; Andrew B Lindstrom; Mark J Strynar Journal: Toxicol Sci Date: 2006-01-16 Impact factor: 4.849
Authors: Elin Hardell; Anna Kärrman; Bert van Bavel; Jia Bao; Michael Carlberg; Lennart Hardell Journal: Environ Int Date: 2013-11-16 Impact factor: 9.621
Authors: Stephanie J Frisbee; A Paul Brooks; Arthur Maher; Patsy Flensborg; Susan Arnold; Tony Fletcher; Kyle Steenland; Anoop Shankar; Sarah S Knox; Cecil Pollard; Joel A Halverson; Verónica M Vieira; Chuanfang Jin; Kevin M Leyden; Alan M Ducatman Journal: Environ Health Perspect Date: 2009-07-13 Impact factor: 9.031
Authors: Franco Scinicariello; Melanie C Buser; Lina Balluz; Kimberly Gehle; H Edward Murray; Henry G Abadin; Roberta Attanasio Journal: Chemosphere Date: 2020-06-20 Impact factor: 7.086
Authors: Samantha L Kingsley; Melissa N Eliot; Karl T Kelsey; Antonia M Calafat; Shelley Ehrlich; Bruce P Lanphear; Aimin Chen; Joseph M Braun Journal: Environ Res Date: 2018-05-07 Impact factor: 6.498
Authors: Ning Ding; Siobán D Harlow; John F Randolph; Rita Loch-Caruso; Sung Kyun Park Journal: Hum Reprod Update Date: 2020-09-01 Impact factor: 15.610
Authors: Alyse N Steves; Adam Turry; Brittany Gill; Danielle Clarkson-Townsend; Joshua M Bradner; Ian Bachli; W Michael Caudle; Gary W Miller; Anthony W S Chan; Charles A Easley Journal: Syst Biol Reprod Med Date: 2018-06-18 Impact factor: 3.061
Authors: John Bassler; Alan Ducatman; Meenal Elliott; Sijin Wen; Banrida Wahlang; John Barnett; Matthew C Cave Journal: Environ Pollut Date: 2019-01-18 Impact factor: 8.071
Authors: Antonia M Calafat; Kayoko Kato; Kendra Hubbard; Tao Jia; Julianne Cook Botelho; Lee-Yang Wong Journal: Environ Int Date: 2019-07-31 Impact factor: 9.621