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Literature DB >> 17447773

Photochemical DNA activation.

Hrvoje Lusic¹, Douglas D Young, Mark O Lively, Alexander Deiters.

Abstract

A new photocaged nucleoside was synthesized and incorporated into DNA with the use of standard synthesis conditions. This approach enabled the disruption of specific H-bonds and allowed for the analysis of their contribution to the activity of a DNAzyme. Brief irradiation with nonphotodamaging UV light led to rapid decaging and almost quantitative restoration of DNAzyme activity. The developed strategy has the potential to find widespread application in the light-induced regulation of oligonucleotide function.

Entities: Chemical

Mesh：

Substances：
DNA, Catalytic
RNA

Year: 2007 PMID： 17447773 PMCID： PMC2532984 DOI： 10.1021/ol070455u

Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005

26 in total

Review 1. Using photolabile ligands in drug discovery and development.

Authors: G Dormán; G D Prestwich
Journal: Trends Biotechnol Date: 2000-02 Impact factor: 19.536

Review 2. Catalytic DNA: a novel tool for gene suppression.

Authors: M J Cairns; E G Saravolac; L Q Sun
Journal: Curr Drug Targets Date: 2002-06 Impact factor: 3.465

Review 3. Approaches for the sequence-specific knockdown of mRNA.

Authors: Lisa J Scherer; John J Rossi
Journal: Nat Biotechnol Date: 2003-12 Impact factor: 54.908

Review 4. The chemical repertoire of natural ribozymes.

Authors: Jennifer A Doudna; Thomas R Cech
Journal: Nature Date: 2002-07-11 Impact factor: 49.962

Review 5. Gene regulation by riboswitches.

Authors: Maumita Mandal; Ronald R Breaker
Journal: Nat Rev Mol Cell Biol Date: 2004-06 Impact factor: 94.444

6. Triggering DNAzymes with light: a photoactive C8 thioether-linked adenosine.

Authors: Richard Ting; Leonard Lermer; David M Perrin
Journal: J Am Chem Soc Date: 2004-10-13 Impact factor: 15.419

7. Photo-mediated gene activation using caged RNA/DNA in zebrafish embryos.

Authors: H Ando; T Furuta; R Y Tsien; H Okamoto
Journal: Nat Genet Date: 2001-08 Impact factor: 38.330

8. Light-regulated catalysis by an RNA-cleaving deoxyribozyme.

Authors: Yong Liu; Dipankar Sen
Journal: J Mol Biol Date: 2004-08-20 Impact factor: 5.469

9. Optimisation of the 10-23 DNAzyme-substrate pairing interactions enhanced RNA cleavage activity at purine-cytosine target sites.

Authors: Murray J Cairns; Andrew King; Lun-Quan Sun
Journal: Nucleic Acids Res Date: 2003-06-01 Impact factor: 16.971

10. Sequence requirements in the catalytic core of the "10-23" DNA enzyme.

Authors: Zaneta Zaborowska; Jens P Fürste; Volker A Erdmann; Jens Kurreck
Journal: J Biol Chem Date: 2002-08-20 Impact factor: 5.157

37 in total

1. Improved synthesis of the two-photon caging group 3-nitro-2-ethyldibenzofuran and its application to a caged thymidine phosphoramidite.

Authors: Hrvoje Lusic; Rajendra Uprety; Alexander Deiters
Journal: Org Lett Date: 2010-03-05 Impact factor: 6.005

Photochemical DNA activation.

Review 1. Using photolabile ligands in drug discovery and development.

Review 2. Catalytic DNA: a novel tool for gene suppression.

Review 3. Approaches for the sequence-specific knockdown of mRNA.

Review 4. The chemical repertoire of natural ribozymes.

Review 5. Gene regulation by riboswitches.

6. Triggering DNAzymes with light: a photoactive C8 thioether-linked adenosine.

7. Photo-mediated gene activation using caged RNA/DNA in zebrafish embryos.

8. Light-regulated catalysis by an RNA-cleaving deoxyribozyme.

9. Optimisation of the 10-23 DNAzyme-substrate pairing interactions enhanced RNA cleavage activity at purine-cytosine target sites.

10. Sequence requirements in the catalytic core of the "10-23" DNA enzyme.

1. Improved synthesis of the two-photon caging group 3-nitro-2-ethyldibenzofuran and its application to a caged thymidine phosphoramidite.

2. Very fast CRISPR on demand.

3. Light-triggered polymerase chain reaction.

4. Light-regulated RNA-small molecule interactions.

5. Light-activated deoxyguanosine: photochemical regulation of peroxidase activity.

6. Spatiotemporal Control of CRISPR/Cas9 Function in Cells and Zebrafish using Light-Activated Guide RNA.

Review 7. Optochemical Control of Biological Processes in Cells and Animals.

8. Optically Triggered Immune Response through Photocaged Oligonucleotides.

9. Turning the 10-23 DNAzyme on and off with light.

10. Restriction enzyme-free mutagenesis via the light regulation of DNA polymerization.