Literature DB >> 17447772

Combinatorial mutasynthesis of flavonoid analogues from acrylic acids in microorganisms.

Joseph A Chemler1, Yajun Yan, Effendi Leonard, Mattheos A G Koffas.   

Abstract

Flavonoids are plant secondary metabolites often used as nutraceutical supplements, but a growing number of unnatural flavonoids are being investigated as therapeutic agents. Cultures of Saccharomyces cerevisiae expressing recombinant flavonoid enzymes, including 4-coumaroyl:CoA ligase (4CL), chalcone synthase (CHS), chalcone isomerase (CHI), and flavanone 3beta-hydroxylase (FHT), produced novel flavanones and dihydroflavonols when fed with a number of aromatic acrylic acids. The flavonoid network also exhibited broad substrate specificity by converting muconic acid into a unique polypropanoid.

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Year:  2007        PMID： 17447772     DOI： 10.1021/ol0703736

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  12 in total

1.  Expanding the repertoire of biofuel alternatives through metabolic pathway evolution.

Authors:  Mattheos A G Koffas
Journal:  Proc Natl Acad Sci U S A       Date:  2009-01-21       Impact factor: 11.205

2.  Biochemical and structural characterization of germicidin synthase: analysis of a type III polyketide synthase that employs acyl-ACP as a starter unit donor.

Authors:  Joseph A Chemler; Tonia J Buchholz; Todd W Geders; David L Akey; Christopher M Rath; George E Chlipala; Janet L Smith; David H Sherman
Journal:  J Am Chem Soc       Date:  2012-04-23       Impact factor: 15.419

3.  Increased malonyl coenzyme A biosynthesis by tuning the Escherichia coli metabolic network and its application to flavanone production.

Authors:  Zachary L Fowler; William W Gikandi; Mattheos A G Koffas
Journal:  Appl Environ Microbiol       Date:  2009-07-24       Impact factor: 4.792

4.  Engineering of artificial plant cytochrome P450 enzymes for synthesis of isoflavones by Escherichia coli.

Authors:  Effendi Leonard; Mattheos A G Koffas
Journal:  Appl Environ Microbiol       Date:  2007-09-28       Impact factor: 4.792

5.  Synthesis and biological evaluation of 5,7-dihydroxyflavanone derivatives as antimicrobial agents.

Authors:  Xing Zhang; Omar Khalidi; So Young Kim; Ruitong Wang; Victor Schultz; Brady F Cress; Richard A Gross; Mattheos A G Koffas; Robert J Linhardt
Journal:  Bioorg Med Chem Lett       Date:  2016-05-04       Impact factor: 2.823

6.  Development of non-natural flavanones as antimicrobial agents.

Authors:  Zachary L Fowler; Karan Shah; John C Panepinto; Amy Jacobs; Mattheos A G Koffas
Journal:  PLoS One       Date:  2011-10-19       Impact factor: 3.240

Review 7.  Engineering microbes for plant polyketide biosynthesis.

Authors:  François-Xavier Lussier; David Colatriano; Zach Wiltshire; Jonathan E Page; Vincent J J Martin
Journal:  Comput Struct Biotechnol J       Date:  2013-02-22       Impact factor: 7.271

Review 8.  When plants produce not enough or at all: metabolic engineering of flavonoids in microbial hosts.

Authors:  Emmanouil A Trantas; Mattheos A G Koffas; Peng Xu; Filippos Ververidis
Journal:  Front Plant Sci       Date:  2015-01-29       Impact factor: 5.753

9.  Improving acetyl-CoA biosynthesis in Saccharomyces cerevisiae via the overexpression of pantothenate kinase and PDH bypass.

Authors:  Wenshan Liu; Bo Zhang; Rongrong Jiang
Journal:  Biotechnol Biofuels       Date:  2017-02-17       Impact factor: 6.040

10.  Yeast artificial chromosomes employed for random assembly of biosynthetic pathways and production of diverse compounds in Saccharomyces cerevisiae.

Authors:  Michael Naesby; Søren Vs Nielsen; Curt Af Nielsen; Trine Green; Thomas O Tange; Ernesto Simón; Philipp Knechtle; Anders Hansson; Markus S Schwab; Olca Titiz; Christophe Folly; Roberto E Archila; Milena Maver; Stephan van Sint Fiet; Thiamo Boussemghoune; Michael Janes; A S Sathish Kumar; Shailendra P Sonkar; Partha P Mitra; V Ajai Kumar Benjamin; Nimitha Korrapati; Inala Suman; Esben H Hansen; Tanja Thybo; Neil Goldsmith; Alexandra Santana Sorensen
Journal:  Microb Cell Fact       Date:  2009-08-13       Impact factor: 5.328
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