Literature DB >> 17446695

Chemomicin A, a new angucyclinone antibiotic produced by Nocardia mediterranei subsp. kanglensis 1747-64.

Cheng-Hang Sun1, Yue Wang, Zheng Wang, Jian-Qin Zhou, Wen-Zao Jin, Xue-Fu You, Hong Gao, Li-Xun Zhao, Shu-Yi Si, Xue Li.   

Abstract

A new angucyclinone antibiotic, chemomicin A was isolated from cultured broth of Nocardia mediterranei subsp. kanglensis 1747-64. Its chemical structure was determined to be 1,2,3,4a,5,6,6a,12a,12b-nonahydro-1,2,3,8,12,12b-hexahydroxy-3-methyl-6a,12a-epoxybenz[a]anthracen-4,7(12H)-dione by a detailed spectroscopic analysis. Chemomicin A had antimicrobial activity against Bacillus subtilis and Enterococcus faecium with MIC values of 10.2 and 20.4 microM, respectively, and showed cytotoxicity against human colorectal cancer HCT116 cells and human esophageal carcinoma YES-2 cells with IC50 values of 127 and 153 microM, respectively.

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Year:  2007        PMID： 17446695     DOI： 10.1038/ja.2007.25

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  10 in total

1.  Landomycins P-W, cytotoxic angucyclines from Streptomyces cyanogenus S-136.

Authors:  Khaled A Shaaban; Sowmyalakshmi Srinivasan; Raj Kumar; Chendil Damodaran; Jürgen Rohr
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2.  Peptidolipins B-F, antibacterial lipopeptides from an ascidian-derived Nocardia sp.

Authors:  Thomas P Wyche; Yanpeng Hou; Emmanuel Vazquez-Rivera; Doug Braun; Tim S Bugni
Journal:  J Nat Prod       Date:  2012-04-06       Impact factor: 4.050

3.  Moromycins A and B, isolation and structure elucidation of C-glycosylangucycline-type antibiotics from Streptomyces sp. KY002.

Authors:  Mohamed S Abdelfattah; Madan Kumar Kharel; John Andrew Hitron; Irfan Baig; Jürgen Rohr
Journal:  J Nat Prod       Date:  2008-07-31       Impact factor: 4.050

4.  Kiamycin, a unique cytotoxic angucyclinone derivative from a marine Streptomyces sp.

Authors:  Zeping Xie; Bing Liu; Hongpeng Wang; Shengxiang Yang; Hongyu Zhang; Yipeng Wang; Naiyun Ji; Song Qin; Hartmut Laatsch
Journal:  Mar Drugs       Date:  2012-02-27       Impact factor: 6.085

5.  Actinomycetes from the South China Sea sponges: isolation, diversity, and potential for aromatic polyketides discovery.

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Journal:  Front Microbiol       Date:  2015-10-01       Impact factor: 5.640

6.  Production of bioactive compounds by actinomycetes and their antioxidant properties.

Authors:  Avilala Janardhan; Arthala Praveen Kumar; Buddolla Viswanath; D V R Saigopal; Golla Narasimha
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7.  Evaluation of bioactive compounds produced by Nocardia levis MK-VL_113 & Streptomyces tendae TK-VL_333 for cytotoxic activity.

Authors:  Kavitha Alapati; Vijayalakshmi Muvva
Journal:  Indian J Med Res       Date:  2013-02       Impact factor: 2.375

8.  Broad Spectrum Antimicrobial Activity of Forest-Derived Soil Actinomycete, Nocardia sp. PB-52.

Authors:  Priyanka Sharma; Mohan C Kalita; Debajit Thakur
Journal:  Front Microbiol       Date:  2016-03-18       Impact factor: 5.640

9.  Bioactive Potential of Several Actinobacteria Isolated from Microbiologically Barely Explored Desert Habitat, Saudi Arabia.

Authors:  Mohammed S Almuhayawi; Mahmoud S M Mohamed; Mohamed Abdel-Mawgoud; Samy Selim; Soad K Al Jaouni; Hamada AbdElgawad
Journal:  Biology (Basel)       Date:  2021-03-19

Review 10.  Bioinoculants-Natural Biological Resources for Sustainable Plant Production.

Authors:  Sagar Maitra; Marian Brestic; Preetha Bhadra; Tanmoy Shankar; Subhashisa Praharaj; Jnana Bharati Palai; M Mostafizur Rahman Shah; Viliam Barek; Peter Ondrisik; Milan Skalický; Akbar Hossain
Journal:  Microorganisms       Date:  2021-12-27
  10 in total

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