Literature DB >> 17439123

Sir2 deacetylases exhibit nucleophilic participation of acetyl-lysine in NAD+ cleavage.

Brian C Smith1, John M Denu.   

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Year:  2007        PMID： 17439123      PMCID： PMC2568996          DOI： 10.1021/ja070162w

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


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  23 in total

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Review 2.  A family of killer toxins. Exploring the mechanism of ADP-ribosylating toxins.

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3.  Kinetic isotope effect characterization of the transition state for oxidized nicotinamide adenine dinucleotide hydrolysis by pertussis toxin.

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5.  Substituent constants for correlation analysis.

Authors:  C Hansch; S D Rockwell; P Y Jow; A Leo; E E Steller
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6.  Sir2 protein deacetylases: evidence for chemical intermediates and functions of a conserved histidine.

Authors:  Brian C Smith; John M Denu
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7.  Substrate specificity and kinetic mechanism of the Sir2 family of NAD+-dependent histone/protein deacetylases.

Authors:  Margie T Borra; Michael R Langer; James T Slama; John M Denu
Journal:  Biochemistry       Date:  2004-08-03       Impact factor: 3.162

Review 8.  NAD hydrolysis: chemical and enzymatic mechanisms.

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9.  Sir2 regulation by nicotinamide results from switching between base exchange and deacetylation chemistry.

Authors:  Anthony A Sauve; Vern L Schramm
Journal:  Biochemistry       Date:  2003-08-12       Impact factor: 3.162

10.  Mechanism of cyclization of pyridine nucleotides by bovine spleen NAD+ glycohydrolase.

Authors:  H M Muller-Steffner; A Augustin; F Schuber
Journal:  J Biol Chem       Date:  1996-09-27       Impact factor: 5.157
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  26 in total

1.  Highly dissociative and concerted mechanism for the nicotinamide cleavage reaction in Sir2Tm enzyme suggested by ab initio QM/MM molecular dynamics simulations.

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Journal:  J Am Chem Soc       Date:  2008-12-10       Impact factor: 15.419

Review 2.  Histones: at the crossroads of peptide and protein chemistry.

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3.  Kinetic and Structural Basis for Acyl-Group Selectivity and NAD(+) Dependence in Sirtuin-Catalyzed Deacylation.

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4.  Mechanism-Based Inhibitors of the Human Sirtuin 5 Deacylase: Structure-Activity Relationship, Biostructural, and Kinetic Insight.

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6.  Sirtuin Deacetylation Mechanism and Catalytic Role of the Dynamic Cofactor Binding Loop.

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Review 7.  Structural basis for sirtuin function: what we know and what we don't.

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8.  A continuous microplate assay for sirtuins and nicotinamide-producing enzymes.

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Review 9.  Chemical mechanisms of histone lysine and arginine modifications.

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10.  SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1.

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Journal:  J Biol Chem       Date:  2010-01-08       Impact factor: 5.157
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