Literature DB >> 17435759

Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia.

Idoya Lahortiga1, Kim De Keersmaecker, Pieter Van Vlierberghe, Carlos Graux, Barbara Cauwelier, Frederic Lambert, Nicole Mentens, H Berna Beverloo, Rob Pieters, Frank Speleman, Maria D Odero, Marijke Bauters, Guy Froyen, Peter Marynen, Peter Vandenberghe, Iwona Wlodarska, Jules P P Meijerink, Jan Cools.   

Abstract

We identified a duplication of the MYB oncogene in 8.4% of individuals with T cell acute lymphoblastic leukemia (T-ALL) and in five T-ALL cell lines. The duplication is associated with a threefold increase in MYB expression, and knockdown of MYB expression initiates T cell differentiation. Our results identify duplication of MYB as an oncogenic event and suggest that MYB could be a therapeutic target in human T-ALL.

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Year:  2007        PMID： 17435759     DOI： 10.1038/ng2025

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  104 in total

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Review 2.  New tricks from an old oncogene: gene fusion and copy number alterations of MYB in human cancer.

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Journal:  Cell Cycle       Date:  2010-08-28       Impact factor: 4.534

3.  An isoform-specific C/EBPβ inhibitor targets acute myeloid leukemia cells.

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4.  WT1 mutations in T-ALL.

Authors:  Valeria Tosello; Marc R Mansour; Kelly Barnes; Maddalena Paganin; Maria Luisa Sulis; Sarah Jenkinson; Christopher G Allen; Rosemary E Gale; David C Linch; Teresa Palomero; Pedro Real; Vundavalli Murty; Xiaopan Yao; Susan M Richards; Anthony Goldstone; Jacob Rowe; Giuseppe Basso; Peter H Wiernik; Elisabeth Paietta; Rob Pieters; Martin Horstmann; Jules P P Meijerink; Adolfo A Ferrando
Journal:  Blood       Date:  2009-06-03       Impact factor: 22.113

5.  The NOTCH signaling pathway: role in the pathogenesis of T-cell acute lymphoblastic leukemia and implication for therapy.

Authors:  Valeria Tosello; Adolfo A Ferrando
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6.  Stress-induced phosphorylation of Thr486 in c-Myb by p38 mitogen-activated protein kinases attenuates conjugation of SUMO-2/3.

Authors:  Juraj Bies; Marek Sramko; Linda Wolff
Journal:  J Biol Chem       Date:  2013-11-20       Impact factor: 5.157

7.  Deletion of the protein tyrosine phosphatase gene PTPN2 in T-cell acute lymphoblastic leukemia.

Authors:  Maria Kleppe; Idoya Lahortiga; Tiama El Chaar; Kim De Keersmaecker; Nicole Mentens; Carlos Graux; Katrien Van Roosbroeck; Adolfo A Ferrando; Anton W Langerak; Jules P P Meijerink; François Sigaux; Torsten Haferlach; Iwona Wlodarska; Peter Vandenberghe; Jean Soulier; Jan Cools
Journal:  Nat Genet       Date:  2010-05-16       Impact factor: 38.330

Review 8.  Pediatric low-grade gliomas: how modern biology reshapes the clinical field.

Authors:  Guillaume Bergthold; Pratiti Bandopadhayay; Wenya Linda Bi; Lori Ramkissoon; Charles Stiles; Rosalind A Segal; Rameen Beroukhim; Keith L Ligon; Jacques Grill; Mark W Kieran
Journal:  Biochim Biophys Acta       Date:  2014-02-28

9.  The c-myb proto-oncogene and microRNA-15a comprise an active autoregulatory feedback loop in human hematopoietic cells.

Authors:  Huiwu Zhao; Anna Kalota; Shenghao Jin; Alan M Gewirtz
Journal:  Blood       Date:  2008-09-25       Impact factor: 22.113

10.  miR-150 Regulates Memory CD8 T Cell Differentiation via c-Myb.

Authors:  Zeyu Chen; Erietta Stelekati; Makoto Kurachi; Sixiang Yu; Zhangying Cai; Sasikanth Manne; Omar Khan; Xiaolu Yang; E John Wherry
Journal:  Cell Rep       Date:  2017-09-12       Impact factor: 9.423
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