Literature DB >> 26854027

An isoform-specific C/EBPβ inhibitor targets acute myeloid leukemia cells.

A Jakobs1, S Uttarkar1, C Schomburg2, S Steinmann1, A Coulibaly1, P Schlenke3, W E Berdel4, C Müller-Tidow5, T J Schmidt2, K-H Klempnauer1.   

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Year:  2016        PMID： 26854027     DOI： 10.1038/leu.2016.16

Source DB:  PubMed          Journal:  Leukemia        ISSN： 0887-6924            Impact factor:   11.528


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  15 in total

1.  A C/EBP beta isoform recruits the SWI/SNF complex to activate myeloid genes.

Authors:  E Kowenz-Leutz; A Leutz
Journal:  Mol Cell       Date:  1999-11       Impact factor: 17.970

Review 2.  MYB function in normal and cancer cells.

Authors:  Robert G Ramsay; Thomas J Gonda
Journal:  Nat Rev Cancer       Date:  2008-07       Impact factor: 60.716

Review 3.  Molecular interaction studies using microscale thermophoresis.

Authors:  Moran Jerabek-Willemsen; Chistoph J Wienken; Dieter Braun; Philipp Baaske; Stefan Duhr
Journal:  Assay Drug Dev Technol       Date:  2011-08       Impact factor: 1.738

4.  Oncogene regulation. An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element.

Authors:  Marc R Mansour; Brian J Abraham; Lars Anders; Alla Berezovskaya; Alejandro Gutierrez; Adam D Durbin; Julia Etchin; Lee Lawton; Stephen E Sallan; Lewis B Silverman; Mignon L Loh; Stephen P Hunger; Takaomi Sanda; Richard A Young; A Thomas Look
Journal:  Science       Date:  2014-11-13       Impact factor: 47.728

5.  Inhibition of Myb-dependent gene expression by the sesquiterpene lactone mexicanin-I.

Authors:  T Bujnicki; C Wilczek; C Schomburg; F Feldmann; P Schlenke; C Müller-Tidow; T J Schmidt; K-H Klempnauer
Journal:  Leukemia       Date:  2011-10-11       Impact factor: 11.528

Review 6.  Role and potential for therapeutic targeting of MYB in leukemia.

Authors:  D R Pattabiraman; T J Gonda
Journal:  Leukemia       Date:  2012-08-09       Impact factor: 11.528

7.  Translational control of C/EBPalpha and C/EBPbeta isoform expression.

Authors:  C F Calkhoven; C Müller; A Leutz
Journal:  Genes Dev       Date:  2000-08-01       Impact factor: 11.361

8.  C/EBPbeta regulates transcription factors critical for proliferation and survival of multiple myeloma cells.

Authors:  Rekha Pal; Martin Janz; Deborah L Galson; Margarete Gries; Shirong Li; Korinna Jöhrens; Ioannis Anagnostopoulos; Bernd Dörken; Markus Y Mapara; Lisa Borghesi; Lela Kardava; G David Roodman; Christine Milcarek; Suzanne Lentzsch
Journal:  Blood       Date:  2009-08-28       Impact factor: 22.113

9.  The C-MYB locus is involved in chromosomal translocation and genomic duplications in human T-cell acute leukemia (T-ALL), the translocation defining a new T-ALL subtype in very young children.

Authors:  Emmanuelle Clappier; Wendy Cuccuini; Anna Kalota; Antoine Crinquette; Jean-Michel Cayuela; Willem A Dik; Anton W Langerak; Bertrand Montpellier; Bertrand Nadel; Pierre Walrafen; Olivier Delattre; Alain Aurias; Thierry Leblanc; Hervé Dombret; Alan M Gewirtz; André Baruchel; Francois Sigaux; Jean Soulier
Journal:  Blood       Date:  2007-04-23       Impact factor: 22.113

10.  Hierarchical maintenance of MLL myeloid leukemia stem cells employs a transcriptional program shared with embryonic rather than adult stem cells.

Authors:  Tim C P Somervaille; Christina J Matheny; Gary J Spencer; Masayuki Iwasaki; John L Rinn; Daniela M Witten; Howard Y Chang; Sheila A Shurtleff; James R Downing; Michael L Cleary
Journal:  Cell Stem Cell       Date:  2009-02-06       Impact factor: 24.633
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  9 in total

Review 1.  Transcription Factor Inhibition: Lessons Learned and Emerging Targets.

Authors:  Andrew Chen; Angela N Koehler
Journal:  Trends Mol Med       Date:  2020-02-15       Impact factor: 11.951

2.  Helenalin Acetate, a Natural Sesquiterpene Lactone with Anti-inflammatory and Anti-cancer Activity, Disrupts the Cooperation of CCAAT Box/Enhancer-binding Protein β (C/EBPβ) and Co-activator p300.

Authors:  Anke Jakobs; Simone Steinmann; Sarah Marie Henrich; Thomas J Schmidt; Karl-Heinz Klempnauer
Journal:  J Biol Chem       Date:  2016-11-01       Impact factor: 5.157

3.  Function-Oriented and Modular (+/-)-cis-Pseudoguaianolide Synthesis: Discovery of New Nrf2 Activators and NF-κB Inhibitors.

Authors:  Fabien Emmetiere; Ranjala Ratnayake; Henry A M Schares; Katherine F M Jones; Emily Bevan-Smith; Hendrik Luesch; Daniel A Harki; Alexander J Grenning
Journal:  Chemistry       Date:  2021-02-26       Impact factor: 5.236

Review 4.  Natural Products with Antitumor Potential Targeting the MYB-C/EBPβ-p300 Transcription Module.

Authors:  Thomas J Schmidt; Karl-Heinz Klempnauer
Journal:  Molecules       Date:  2022-03-23       Impact factor: 4.411

5.  A novel cell-based screening assay for small-molecule MYB inhibitors identifies podophyllotoxins teniposide and etoposide as inhibitors of MYB activity.

Authors:  Maria Yusenko; Anke Jakobs; Karl-Heinz Klempnauer
Journal:  Sci Rep       Date:  2018-09-03       Impact factor: 4.379

6.  JMJD3 facilitates C/EBPβ-centered transcriptional program to exert oncorepressor activity in AML.

Authors:  Shan-He Yu; Kang-Yong Zhu; Juan Chen; Xiang-Zhen Liu; Peng-Fei Xu; Wu Zhang; Li Yan; He-Zhou Guo; Jiang Zhu
Journal:  Nat Commun       Date:  2018-08-22       Impact factor: 14.919

7.  Aberrant enhancer hypomethylation contributes to hepatic carcinogenesis through global transcriptional reprogramming.

Authors:  Lei Xiong; Feng Wu; Qiong Wu; Liangliang Xu; Otto K Cheung; Wei Kang; Myth T Mok; Lemuel L M Szeto; Cheuk-Yin Lun; Raymond W Lung; Jinglin Zhang; Ken H Yu; Sau-Dan Lee; Guangcun Huang; Chiou-Miin Wang; Joseph Liu; Zhuo Yu; Dae-Yeul Yu; Jian-Liang Chou; Wan-Hong Huang; Bo Feng; Yue-Sun Cheung; Paul B Lai; Patrick Tan; Nathalie Wong; Michael W Chan; Tim H Huang; Kevin Y Yip; Alfred S Cheng; Ka-Fai To
Journal:  Nat Commun       Date:  2019-01-18       Impact factor: 14.919

8.  C/EBPβ is a MYB- and p300-cooperating pro-leukemogenic factor and promising drug target in acute myeloid leukemia.

Authors:  Maria V Yusenko; Amke Trentmann; Debora A Casolari; Luca Abdel Ghani; Mairin Lenz; Melanie Horn; Wolfgang Dörner; Stefan Klempnauer; Henning D Mootz; Maria Francisca Arteaga; Jan-Henrik Mikesch; Richard J D'Andrea; Thomas J Gonda; Carsten Müller-Tidow; Thomas J Schmidt; Karl-Heinz Klempnauer
Journal:  Oncogene       Date:  2021-05-06       Impact factor: 9.867

9.  The natural anti-tumor compound Celastrol targets a Myb-C/EBPβ-p300 transcriptional module implicated in myeloid gene expression.

Authors:  Anna Coulibaly; Astrid Haas; Simone Steinmann; Anke Jakobs; Thomas J Schmidt; Karl-Heinz Klempnauer
Journal:  PLoS One       Date:  2018-02-02       Impact factor: 3.240
  9 in total

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