Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Optimal specificity and function for flexible biomolecular recognition.

Literature DB >> 17416623

Optimal specificity and function for flexible biomolecular recognition.

Abstract

Biomolecular associations often accompanied by large conformational changes, sometimes folding and unfolding. By exploring an exactly solvable model, we constructed the free energy landscape and established a general framework for studying the biomolecular flexible binding process. We derived an optimal criterion for the specificity and function for flexible biomolecular binding where the binding and conformational folding are coupled.

Mesh：

Substances：

Year: 2007 PMID： 17416623 PMCID： PMC1877770 DOI： 10.1529/biophysj.107.105551

Source DB: PubMed Journal: Biophys J ISSN： 0006-3495 Impact factor: 4.033

11 in total

Review 1. Coupling of folding and binding for unstructured proteins.

Authors: H Jane Dyson; Peter E Wright
Journal: Curr Opin Struct Biol Date: 2002-02 Impact factor: 6.809

2. Intrinsic disorder and protein function.

Authors: A Keith Dunker; Celeste J Brown; J David Lawson; Lilia M Iakoucheva; Zoran Obradović
Journal: Biochemistry Date: 2002-05-28 Impact factor: 3.162

3. The physics and bioinformatics of binding and folding-an energy landscape perspective.

Authors: Garegin A Papoian; Peter G Wolynes
Journal: Biopolymers Date: 2003-03 Impact factor: 2.505

4. Protein topology determines binding mechanism.

Authors: Yaakov Levy; Peter G Wolynes; José N Onuchic
Journal: Proc Natl Acad Sci U S A Date: 2003-12-23 Impact factor: 11.205

5. Folding at the speed limit.

Authors: Wei Yuan Yang; Martin Gruebele
Journal: Nature Date: 2003-05-08 Impact factor: 49.962

6. Energy landscape theory, funnels, specificity, and optimal criterion of biomolecular binding.

Authors: Jin Wang; Gennady M Verkhivker
Journal: Phys Rev Lett Date: 2003-05-06 Impact factor: 9.161

7. Optimal protein-folding codes from spin-glass theory.

Authors: R A Goldstein; Z A Luthey-Schulten; P G Wolynes
Journal: Proc Natl Acad Sci U S A Date: 1992-06-01 Impact factor: 11.205

8. Application of a Theory of Enzyme Specificity to Protein Synthesis.

Authors: D E Koshland
Journal: Proc Natl Acad Sci U S A Date: 1958-02 Impact factor: 11.205

Review 9. Theory of biomolecular recognition.

Authors: J A McCammon
Journal: Curr Opin Struct Biol Date: 1998-04 Impact factor: 6.809

10. Single-molecule dynamics reveals cooperative binding-folding in protein recognition.

Authors: Jin Wang; Qiang Lu; H Peter Lu
Journal: PLoS Comput Biol Date: 2006-05-16 Impact factor: 4.475

13 in total

1. The ruggedness of protein-protein energy landscape and the cutoff for 1/r(n) potentials.

Authors: Anatoly M Ruvinsky; Ilya A Vakser
Journal: Bioinformatics Date: 2009-02-23 Impact factor: 6.937

2. Quantifying the topography of the intrinsic energy landscape of flexible biomolecular recognition.

Authors: Xiakun Chu; Linfeng Gan; Erkang Wang; Jin Wang
Journal: Proc Natl Acad Sci U S A Date: 2013-06-10 Impact factor: 11.205

3. Multiscaled exploration of coupled folding and binding of an intrinsically disordered molecular recognition element in measles virus nucleoprotein.

Authors: Yong Wang; Xiakun Chu; Sonia Longhi; Philippe Roche; Wei Han; Erkang Wang; Jin Wang
Journal: Proc Natl Acad Sci U S A Date: 2013-09-16 Impact factor: 11.205

Optimal specificity and function for flexible biomolecular recognition.

Review 1. Coupling of folding and binding for unstructured proteins.

2. Intrinsic disorder and protein function.

3. The physics and bioinformatics of binding and folding-an energy landscape perspective.

4. Protein topology determines binding mechanism.

5. Folding at the speed limit.

6. Energy landscape theory, funnels, specificity, and optimal criterion of biomolecular binding.

7. Optimal protein-folding codes from spin-glass theory.

8. Application of a Theory of Enzyme Specificity to Protein Synthesis.

Review 9. Theory of biomolecular recognition.

10. Single-molecule dynamics reveals cooperative binding-folding in protein recognition.

1. The ruggedness of protein-protein energy landscape and the cutoff for 1/r(n) potentials.

2. Quantifying the topography of the intrinsic energy landscape of flexible biomolecular recognition.

3. Multiscaled exploration of coupled folding and binding of an intrinsically disordered molecular recognition element in measles virus nucleoprotein.

4. Chasing funnels on protein-protein energy landscapes at different resolutions.

5. Predictive energy landscapes for protein-protein association.

6. Funneled energy landscape unifies principles of protein binding and evolution.

7. Molecular mechanism of multispecific recognition of Calmodulin through conformational changes.

Review 8. The importance of being flexible: the case of basic region leucine zipper transcriptional regulators.

9. Intrinsic disorder in protein interactions: insights from a comprehensive structural analysis.

10. Structural and functional implications of p53 missense cancer mutations.