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Literature DB >> 17412959

Regulation of a cyclin-CDK-CDK inhibitor complex by inositol pyrophosphates.

Young-Sam Lee¹, Sashidhar Mulugu, John D York, Erin K O'Shea.

Abstract

In budding yeast, phosphate starvation triggers inhibition of the Pho80-Pho85 cyclin-cyclin-dependent kinase (CDK) complex by the CDK inhibitor Pho81, leading to expression of genes involved in nutrient homeostasis. We isolated myo-d-inositol heptakisphosphate (IP7) as a cellular component that stimulates Pho81-dependent inhibition of Pho80-Pho85. IP7 is necessary for Pho81-dependent inhibition of Pho80-Pho85 in vitro. Moreover, intracellular concentrations of IP7 increased upon phosphate starvation, and yeast mutants defective in IP7 production failed to inhibit Pho80-Pho85 in response to phosphate starvation. These observations reveal regulation of a cyclin-CDK complex by a metabolite and suggest that a complex metabolic network mediates signaling of phosphate availability.

Entities: Chemical Gene Species

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Year: 2007 PMID： 17412959 PMCID： PMC2211727 DOI： 10.1126/science.1139080

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

24 in total

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Authors: Wayne A Wilson; Peter J Roach
Journal: Cell Date: 2002-10-18 Impact factor: 41.582

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Journal: Science Date: 1994-02-25 Impact factor: 47.728

3. In Saccharomyces cerevisiae, the inositol polyphosphate kinase activity of Kcs1p is required for resistance to salt stress, cell wall integrity, and vacuolar morphogenesis.

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Journal: J Biol Chem Date: 2002-04-15 Impact factor: 5.157

4. Functional analysis of the cyclin-dependent kinase inhibitor Pho81 identifies a novel inhibitory domain.

Authors: S Huang; D A Jeffery; M D Anthony; E K O'Shea
Journal: Mol Cell Biol Date: 2001-10 Impact factor: 4.272

5. Inositol pyrophosphates are required for DNA hyperrecombination in protein kinase c1 mutant yeast.

Authors: Hongbo R Luo; Adolfo Saiardi; Hongbo Yu; Eiichiro Nagata; Keqiang Ye; Solomon H Snyder
Journal: Biochemistry Date: 2002-02-26 Impact factor: 3.162

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Authors: K R Schneider; R L Smith; E K O'Shea
Journal: Science Date: 1994-10-07 Impact factor: 47.728

7. Inositol pyrophosphates mediate chemotaxis in Dictyostelium via pleckstrin homology domain-PtdIns(3,4,5)P3 interactions.

Authors: Hongbo R Luo; Yi Elaine Huang; Jianmeng C Chen; Adolfo Saiardi; Miho Iijima; Keqiang Ye; Yunfei Huang; Eiichiro Nagata; Peter Devreotes; Solomon H Snyder
Journal: Cell Date: 2003-09-05 Impact factor: 41.582

8. Golgi coatomer binds, and forms K(+)-selective channels gated by, inositol polyphosphates.

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Journal: J Biol Chem Date: 1994-07-08 Impact factor: 5.157

9. Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate.

Authors: H Streb; R F Irvine; M J Berridge; I Schulz
Journal: Nature Date: 1983 Nov 3-9 Impact factor: 49.962

10. Inhibition of clathrin assembly by high affinity binding of specific inositol polyphosphates to the synapse-specific clathrin assembly protein AP-3.

Authors: W Ye; N Ali; M E Bembenek; S B Shears; E M Lafer
Journal: J Biol Chem Date: 1995-01-27 Impact factor: 5.157

139 in total

1. Discovery of mutations in Saccharomyces cerevisiae by pooled linkage analysis and whole-genome sequencing.

Authors: Shanda R Birkeland; Natsuko Jin; Alev Cagla Ozdemir; Robert H Lyons; Lois S Weisman; Thomas E Wilson
Journal: Genetics Date: 2010-10-05 Impact factor: 4.562

2. Inositol phosphate kinase Vip1p interacts with histone chaperone Asf1p in Saccharomyces cerevisiae.

Authors: Shigehiro Osada; Kiyoto Kageyama; Yuji Ohnishi; Jun-Ichi Nishikawa; Tsutomu Nishihara; Masayoshi Imagawa
Journal: Mol Biol Rep Date: 2011-12-09 Impact factor: 2.316

3. p53-mediated apoptosis requires inositol hexakisphosphate kinase-2.

Authors: Michael A Koldobskiy; Anutosh Chakraborty; J Kent Werner; Adele M Snowman; Krishna R Juluri; M Scott Vandiver; Seyun Kim; Shira Heletz; Solomon H Snyder
Journal: Proc Natl Acad Sci U S A Date: 2010-11-15 Impact factor: 11.205

4. Asp1 from Schizosaccharomyces pombe binds a [2Fe-2S](2+) cluster which inhibits inositol pyrophosphate 1-phosphatase activity.

Authors: Huanchen Wang; Vasudha S Nair; Ashley A Holland; Samanta Capolicchio; Henning J Jessen; Michael K Johnson; Stephen B Shears
Journal: Biochemistry Date: 2015-10-09 Impact factor: 3.162

10. Inositol Pyrophosphate Kinase Asp1 Modulates Chromosome Segregation Fidelity and Spindle Function in Schizosaccharomyces pombe.

Authors: Boris Topolski; Visnja Jakopec; Natascha A Künzel; Ursula Fleig
Journal: Mol Cell Biol Date: 2016-11-28 Impact factor: 4.272