Literature DB >> 11851397

Inositol pyrophosphates are required for DNA hyperrecombination in protein kinase c1 mutant yeast.

Hongbo R Luo1, Adolfo Saiardi, Hongbo Yu, Eiichiro Nagata, Keqiang Ye, Solomon H Snyder.   

Abstract

Diphosphoinositol pentakisphosphate (InsP(7)) and bis-diphosphoinositol tetrakisphosphate (InsP(8)) contain energetic pyrophosphate groups, occur throughout animal and plant kingdoms, and are synthesized by a recently cloned family of inositol hexakisphosphate kinases (InsP(6)Ks). We report that these inositol pyrophosphates mediate homologous DNA recombination in yeast S. cerevisae. Hyperrecombination, caused by altered protein kinase C1 (PKC1), is lost in yeast with deletion of yeast InsP(6)K (yInsP(6)K) and can be restored selectively by catalytically active yeast or mammalian InsP(6)Ks. Inositol pyrophosphates are required for two forms of hyperrecombination that differ in mechanism, suggesting some generalities for actions of inositol pyrophosphates in recombination.

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Year:  2002        PMID： 11851397     DOI： 10.1021/bi0118153

Source DB:  PubMed          Journal:  Biochemistry        ISSN： 0006-2960            Impact factor:   3.162


  35 in total

Review 1.  How versatile are inositol phosphate kinases?

Authors:  Stephen B Shears
Journal:  Biochem J       Date:  2004-01-15       Impact factor: 3.857

2.  Visualization of inositol phosphate-dependent mobility of Ku: depletion of the DNA-PK cofactor InsP6 inhibits Ku mobility.

Authors:  Jennifer Byrum; Stephen Jordan; Stephen T Safrany; William Rodgers
Journal:  Nucleic Acids Res       Date:  2004-05-18       Impact factor: 16.971

Review 3.  Regulation of immune cell development through soluble inositol-1,3,4,5-tetrakisphosphate.

Authors:  Karsten Sauer; Michael P Cooke
Journal:  Nat Rev Immunol       Date:  2010-04       Impact factor: 53.106

Review 4.  Roles for inositol polyphosphate kinases in the regulation of nuclear processes and developmental biology.

Authors:  Andrew M Seeds; Joshua P Frederick; Marco M K Tsui; John D York
Journal:  Adv Enzyme Regul       Date:  2007-01-05

5.  Paralogous murine Nudt10 and Nudt11 genes have differential expression patterns but encode identical proteins that are physiologically competent diphosphoinositol polyphosphate phosphohydrolases.

Authors:  Len V Hua; Kiyoshi Hidaka; Xavier Pesesse; Larry D Barnes; Stephen B Shears
Journal:  Biochem J       Date:  2003-07-01       Impact factor: 3.857

6.  Cell cycle progression in G1 and S phases is CCR4 dependent following ionizing radiation or replication stress in Saccharomyces cerevisiae.

Authors:  Tammy J Westmoreland; Jeffrey R Marks; John A Olson; Eric M Thompson; Michael A Resnick; Craig B Bennett
Journal:  Eukaryot Cell       Date:  2004-04

Review 7.  Inositol pyrophosphates: structure, enzymology and function.

Authors:  Christopher John Barker; Christopher Illies; Gian Carlo Gaboardi; Per-Olof Berggren
Journal:  Cell Mol Life Sci       Date:  2009-08-28       Impact factor: 9.261

8.  Alterations in an inositol phosphate code through synergistic activation of a G protein and inositol phosphate kinases.

Authors:  James C Otto; Patrick Kelly; Shean-Tai Chiou; John D York
Journal:  Proc Natl Acad Sci U S A       Date:  2007-09-25       Impact factor: 11.205

9.  Role of Plc1p in regulation of Mcm1p-dependent genes.

Authors:  Katarzyna Guzinska; Roger Varghese; Ales Vancura
Journal:  FEMS Microbiol Lett       Date:  2009-05-01       Impact factor: 2.742

Review 10.  The emerging roles of inositol pyrophosphates in eukaryotic cell physiology.

Authors:  Swarna Gowri Thota; Rashna Bhandari
Journal:  J Biosci       Date:  2015-09       Impact factor: 1.826
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