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Literature DB >> 17400458

Polyphenols based on isoflavones as inhibitors of Helicobacter pylori urease.

Zhu-Ping Xiao¹, Da-Hua Shi, Huan-Qiu Li, Li-Na Zhang, Chen Xu, Hai-Liang Zhu.

Abstract

Twenty polyphenols were synthesized and evaluated for their effect on Helicobacter pylori urease. Among these compounds, 4-(p-hydroxyphenethyl)pyrogallol (15) (IC(50)=0.03 mM) and 7,8,4'-trihydroxyisoflavone (19) (IC(50)=0.14 mM) showed potent inhibitory activities, and inhibited Helicobacter pylori urease in a time-dependent manner. The structure-activity relationship of these polyphenols revealed: the two ortho hydroxyl groups were essential for inhibitory activity of polyphenol. When the C-ring of isoflavone was broken, the inhibitory activity markedly decreased. As for deoxybenzoin, the carboxyl group was clearly detrimental.

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Year: 2007 PMID： 17400458 DOI： 10.1016/j.bmc.2007.03.045

Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641

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Cited

21 in total

9. Molecular docking, synthesis, kinetics study, structure-activity relationship and ADMET analysis of morin analogous as Helicobacter pylori urease inhibitors.

Authors: Ritu Kataria; Anurag Khatkar
Journal: BMC Chem Date: 2019-04-01

10. In-silico design, synthesis, ADMET studies and biological evaluation of novel derivatives of Chlorogenic acid against Urease protein and H. Pylori bacterium.

Authors: Ritu Kataria; Anurag Khatkar
Journal: BMC Chem Date: 2019-03-28

Polyphenols based on isoflavones as inhibitors of Helicobacter pylori urease.

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