| Literature DB >> 17391671 |
Kirsten Aigner1, Luise Descovich, Mario Mikula, Aneesa Sultan, Brigitta Dampier, Stefan Bonné, Frans van Roy, Wolfgang Mikulits, Martin Schreiber, Thomas Brabletz, Wolfgang Sommergruber, Norbert Schweifer, Andreas Wernitznig, Hartmut Beug, Roland Foisner, Andreas Eger.
Abstract
Plakophilin 3 (PKP3) belongs to the p120ctn family of armadillo-related proteins predominantly functioning in desmosome formation. Here we report that PKP3 is transcriptionally repressed by the E-cadherin repressor ZEB1 in metastatic cancer cells. ZEB1 physically associates with two conserved E-box elements in the PKP3 promoter and partially represses the activity of corresponding human and mouse PKP3 promoter fragments in reporter gene assays. In human tumours ZEB1 is upregulated in invasive cancer cells at the tumour-host interface, which is accompanied by downregulation of PKP3 expression levels. Hence, the transcriptional repression of PKP3 by ZEB1 contributes to ZEB1-mediated disintegration of intercellular adhesion and epithelial to mesenchymal transition.Entities:
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Year: 2007 PMID： 17391671 PMCID： PMC2938730 DOI： 10.1016/j.febslet.2007.03.026
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124