Early cortical activities evoked by noxious stimulation in humans.

Lasers can selectively activate the nociceptors of A-delta fibers. Since nociceptors in the skin are activated via temperature conduction by the laser beam, a latency jittering of cortical responses among trials would affect results obtained with a conventional averaging (C-AVE) technique. We therefore used a new method, latency-adjusted averaging (L-AVE), to investigate cortical responses to noxious laser stimulation in normal subjects. L-AVE was done by averaging trials after adjusting the latency so that the peak latency of an activity in the temporal region of all trials matched on the time axis. Both in C-AVE and in L-AVE, clear activations were found in the contralateral primary somatosensory cortex (SI) and bilateral parasylvian regions, whose activities peaked 163-181 ms after the stimulation. In addition to these three main activities, weak activities peaking at around 109-119 ms could be identified in only L-AVE in similar cortical regions. Since the direction of the source differed between early and main activities, we considered that the early weak activities were cancelled out by the later main activities with an opposite orientation. The results suggested that early cortical processing of noxious information occurs earlier than previous neurophysiological studies have estimated and that the temporal sequence of activations should be reconsidered.