Current status and future directions of computer-aided diagnosis in mammography.

The concept of computer-aided detection (CADe) was introduced more than 50 years ago; however, only in the last 20 years there have been serious and successful attempts at developing CADe for mammography. CADe schemes have high sensitivity, but poor specificity compared to radiologists. CADe has been shown to help radiologists find more cancers both in observer studies and in clinical evaluations. Clinically, CADe increases the number of cancers detected by approximately 10%, which is comparable to double reading by two radiologists.