| Literature DB >> 17382544 |
John J M Wiener1, Laurent Gomez, Hariharan Venkatesan, Alejandro Santillán, Brett D Allison, Kimberly L Schwarz, Shirin Shinde, Liu Tang, Michael D Hack, Brian J Morrow, S Timothy Motley, Raul M Goldschmidt, Karen Joy Shaw, Todd K Jones, Cheryl A Grice.
Abstract
We have previously reported a novel class of tetrahydroindazoles that display potency against a variety of Gram-positive and Gram-negative bacteria, potentially via interaction with type II bacterial topoisomerases. Herein are reported SAR investigations of this new series. Several compounds possessing broad-spectrum potency were prepared. Further, these compounds exhibit activity against multidrug-resistant Gram-positive microorganisms equivalent to that against susceptible strains.Entities:
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Year: 2007 PMID： 17382544 DOI： 10.1016/j.bmcl.2007.03.004
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823