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Literature DB >> 17377650

Photochemical control of biological processes.

Abstract

Photochemical regulation of biological processes offers a high level of control to study intracellular mechanisms with unprecedented spatial and temporal resolution. This report summarizes the advances made in recent years, focusing predominantly on the in vivo regulation of gene function using irradiation with UV light. The majority of the described applications entail the utilization of photocaging groups installed either on a small molecule modulator of biomolecular function or directly on a biological macromolecule itself.

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Year: 2006 PMID： 17377650 DOI： 10.1039/b616410m

Source DB: PubMed Journal: Org Biomol Chem ISSN： 1477-0520 Impact factor: 3.876

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Cited

54 in total

1. Improved synthesis of the two-photon caging group 3-nitro-2-ethyldibenzofuran and its application to a caged thymidine phosphoramidite.

Authors: Hrvoje Lusic; Rajendra Uprety; Alexander Deiters
Journal: Org Lett Date: 2010-03-05 Impact factor: 6.005

2. Photochemical DNA activation.

Authors: Hrvoje Lusic; Douglas D Young; Mark O Lively; Alexander Deiters
Journal: Org Lett Date: 2007-04-21 Impact factor: 6.005

3. Light-triggered polymerase chain reaction.

Authors: Douglas D Young; Wesleigh F Edwards; Hrvoje Lusic; Mark O Lively; Alexander Deiters
Journal: Chem Commun (Camb) Date: 2007-11-14 Impact factor: 6.222

4. Light-regulated RNA-small molecule interactions.

Authors: Douglas D Young; Alexander Deiters
Journal: Chembiochem Date: 2008-05-23 Impact factor: 3.164

5. Controlling the Oligomerization State of Aβ-Derived Peptides with Light.

Authors: Patrick J Salveson; Sepehr Haerianardakani; Alexander Thuy-Boun; Adam G Kreutzer; James S Nowick
Journal: J Am Chem Soc Date: 2018-04-20 Impact factor: 15.419

Review 6. Illuminating the chemistry of life: design, synthesis, and applications of "caged" and related photoresponsive compounds.

Authors: Hsien-Ming Lee; Daniel R Larson; David S Lawrence
Journal: ACS Chem Biol Date: 2009-06-19 Impact factor: 5.100

Photochemical control of biological processes.

1. Improved synthesis of the two-photon caging group 3-nitro-2-ethyldibenzofuran and its application to a caged thymidine phosphoramidite.

2. Photochemical DNA activation.

3. Light-triggered polymerase chain reaction.

4. Light-regulated RNA-small molecule interactions.

5. Controlling the Oligomerization State of Aβ-Derived Peptides with Light.

Review 6. Illuminating the chemistry of life: design, synthesis, and applications of "caged" and related photoresponsive compounds.

7. A selenide-based approach to photochemical cleavage of peptide and protein backbones at engineered backbone esters.

8. Light-activation of gene function in mammalian cells via ribozymes.

9. Restriction enzyme-free mutagenesis via the light regulation of DNA polymerization.

10. Dependence of aptamer activity on opposed terminal extensions: improvement of light-regulation efficiency.