| Literature DB >> 17368900 |
Muhammed K Uddin1, Serge G Reignier, Tom Coulter, Christian Montalbetti, Charlotta Grånäs, Steven Butcher, Christian Krog-Jensen, Jakob Felding.
Abstract
Syntheses and structure-antiproliferative relationship for oxyphenisatin analogues are described. The cell proliferation data showed that the presence of substituents (especially F, Cl, Me, CF(3), and OMe) in the 6- and 7-position of oxyphenisatin markedly enhanced the potency in the MDA-468 cell line without affecting the MDA-231 cell line. The best compounds from this series showed low nanomolar antiproliferative activity towards the MDA-468 cell line and a 1000-fold selectivity over the MDA-231 cell line.Entities:
Mesh：
Substances：
Year: 2007 PMID： 17368900 DOI： 10.1016/j.bmcl.2007.02.060
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823