| Literature DB >> 17367894 |
Raquel F Rodrigues1, Edson F da Silva, Aurea Echevarria, Renata Fajardo-Bonin, Veronica F Amaral, Leonor L Leon, Marilene M Canto-Cavalheiro.
Abstract
In this first study, a series of mesoionic compounds like 1,3,4-thiadiazolium-2-phenylamine derivatives were synthesized and studied in Leishmania amazonensis. The cytotoxic effects of these compounds on the host cells were investigated and the antileishmanial in vitro activity was compared with other species of Leishmania (Leishmania chagasi and Leishmania braziliensis). The compounds presented lower toxicity in murine macrophages than the reference drug pentamidine. The halogen derivatives 5, 6, 8 and 13 (4-F, 4-Cl, 4-Br and 3-Cl) were the most active compounds among all the species tested.Entities:
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Year: 2007 PMID： 17367894 DOI： 10.1016/j.ejmech.2006.12.026
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514