| Literature DB >> 19015338 |
Raquel F Rodrigues1, Karen S Charret, Edson F da Silva, Aurea Echevarria, Verônica F Amaral, Leonor L Leon, Marilene M Canto-Cavalheiro.
Abstract
The efficacy of two mesoionic derivatives (MI-H-H and MI-4-OCH(3)) was evaluated in CBA/J mice infected with Leishmania amazonensis. Treatment with these compounds demonstrated that the MI-4-OCH(3) derivative and the reference drug meglumine antimoniate (Glucantime) presented significant activity relative to an untreated control. No apparent hepatic or renal toxicity due to these mesoionic compounds was found.Entities:
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Year: 2008 PMID： 19015338 PMCID： PMC2630633 DOI： 10.1128/AAC.00062-08
Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191