Literature DB >> 1736289

Duplication-targeted DNA methylation and mutagenesis in the evolution of eukaryotic chromosomes.

M C Kricker1, J W Drake, M Radman.   

Abstract

Mammalian genomes are threatened with gene inactivation and chromosomal scrambling by recombination between repeated sequences such as mobile genetic elements and pseudogenes. We present and test a model for a defensive strategy based on the methylation and subsequent mutation of CpG dinucleotides in those DNA duplications that create uninterrupted homologous sequences longer than about 0.3 kilobases. The model helps to explain both the diversity of CpG frequencies in different genes and the persistence of gene fragmentation into exons and introns.

Entities:  

Mesh：

Year:  1992        PMID： 1736289      PMCID： PMC48388          DOI： 10.1073/pnas.89.3.1075

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  31 in total

1.  How big is the universe of exons?

Authors:  R L Dorit; L Schoenbach; W Gilbert
Journal:  Science       Date:  1990-12-07       Impact factor: 47.728

Review 2.  Chromosome synapsis and genetic recombination: their roles in meiotic chromosome segregation.

Authors:  G S Roeder
Journal:  Trends Genet       Date:  1990-12       Impact factor: 11.639

Review 3.  CpG-rich islands and the function of DNA methylation.

Authors:  A P Bird
Journal:  Nature       Date:  1986 May 15-21       Impact factor: 49.962

4.  Effect of base pair mismatches on recombination via the RecBCD pathway.

Authors:  P Shen; H V Huang
Journal:  Mol Gen Genet       Date:  1989-08

5.  Differential effects of base-pair mismatch on intrachromosomal versus extrachromosomal recombination in mouse cells.

Authors:  A S Waldman; R M Liskay
Journal:  Proc Natl Acad Sci U S A       Date:  1987-08       Impact factor: 11.205

6.  The methylation-free status of a housekeeping transgene is lost at high copy number.

Authors:  M Mehtali; M LeMeur; R Lathe
Journal:  Gene       Date:  1990-07-16       Impact factor: 3.688

7.  Homologous recombination in Escherichia coli: dependence on substrate length and homology.

Authors:  P Shen; H V Huang
Journal:  Genetics       Date:  1986-03       Impact factor: 4.562

Review 8.  Premeiotic instability of repeated sequences in Neurospora crassa.

Authors:  E U Selker
Journal:  Annu Rev Genet       Date:  1990       Impact factor: 16.830

9.  The human somatic cytochrome c gene: two classes of processed pseudogenes demarcate a period of rapid molecular evolution.

Authors:  M J Evans; R C Scarpulla
Journal:  Proc Natl Acad Sci U S A       Date:  1988-12       Impact factor: 11.205

10.  Hot spots for growth hormone gene deletions in homologous regions outside of Alu repeats.

Authors:  C L Vnencak-Jones; J A Phillips
Journal:  Science       Date:  1990-12-21       Impact factor: 47.728
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  47 in total

1.  Systematic characterisation of disease associated balanced chromosome rearrangements by FISH: cytogenetically and genetically anchored YACs identify microdeletions and candidate regions for mental retardation genes.

Authors:  J Wirth; H G Nothwang; S van der Maarel; C Menzel; G Borck; I Lopez-Pajares; K Brøndum-Nielsen; N Tommerup; M Bugge; H H Ropers; T Haaf
Journal:  J Med Genet       Date:  1999-04       Impact factor: 6.318

2.  Duplication-dependent CG suppression of the seed storage protein genes of maize.

Authors:  Gertrud Lund; Massimiliano Lauria; Per Guldberg; Silvio Zaina
Journal:  Genetics       Date:  2003-10       Impact factor: 4.562

3.  How and Why Do Plants Inactivate Homologous (Trans)genes?

Authors:  M. A. Matzke; AJM. Matzke
Journal:  Plant Physiol       Date:  1995-03       Impact factor: 8.340

4.  Homology-dependent methylation in primate repetitive DNA.

Authors:  Julien Meunier; Adel Khelifi; Vincent Navratil; Laurent Duret
Journal:  Proc Natl Acad Sci U S A       Date:  2005-03-29       Impact factor: 11.205

5.  The GC content of primates and rodents genomes is not at equilibrium: a reply to Antezana.

Authors:  Laurent Duret
Journal:  J Mol Evol       Date:  2006-05-11       Impact factor: 2.395

6.  Native DNA repeats and methylation in Ascobolus.

Authors:  C Goyon; J L Rossignol; G Faugeron
Journal:  Nucleic Acids Res       Date:  1996-09-01       Impact factor: 16.971

7.  Cloning of a mouse protein kinase A catalytic subunit pseudogene and chromosomal mapping of C subunit isoforms.

Authors:  D E Cummings; S Edelhoff; C M Disteche; G S McKnight
Journal:  Mamm Genome       Date:  1994-11       Impact factor: 2.957

8.  Cytosine deaminations catalyzed by DNA cytosine methyltransferases are unlikely to be the major cause of mutational hot spots at sites of cytosine methylation in Escherichia coli.

Authors:  M Wyszynski; S Gabbara; A S Bhagwat
Journal:  Proc Natl Acad Sci U S A       Date:  1994-02-15       Impact factor: 11.205

9.  eth-1, the Neurospora crassa locus encoding S-adenosylmethionine synthetase: molecular cloning, sequence analysis and in vivo overexpression.

Authors:  M R Mautino; J L Barra; A L Rosa
Journal:  Genetics       Date:  1996-03       Impact factor: 4.562

10.  Use of cDNA microarrays to monitor transcriptional responses of the chestnut blight fungus Cryphonectria parasitica to infection by virulence-attenuating hypoviruses.

Authors:  Todd D Allen; Angus L Dawe; Donald L Nuss
Journal:  Eukaryot Cell       Date:  2003-12
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