| Literature DB >> 17348669 |
Paul Zhichkin1, Edward Kesicki, Jennifer Treiberg, Lisa Bourdon, Matthew Ronsheim, Hua Chee Ooi, Stephen White, Angela Judkins, David Fairfax.
Abstract
[structure: see text]. An efficient three-step synthesis of chiral 3H-quinazoline-4-one derivatives from commercial materials is disclosed. The Mumm reaction of imidoyl chloride with alpha-amino acids followed by reductive cyclization affords enantiomerically pure (ee >93%) quinazoline-4-ones in good overall yield. A comparison with existing approaches indicates that this method is superior for hindered substrates.Entities:
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Year: 2007 PMID： 17348669 DOI： 10.1021/ol070276c
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005