Literature DB >> 17345745

A flow reactor process for the synthesis of peptides utilizing immobilized reagents, scavengers and catch and release protocols.

Ian R Baxendale1, Steven V Ley, Christopher D Smith, Geoffrey K Tranmer.   

Abstract

A general flow process for the multi-step assembly of peptides has been developed and this procedure has been used to successfully construct a series of Boc, Cbz and Fmoc N-protected dipeptides in excellent yields and purities, including an extension of the method to enable the preparation of a tripeptide derivative.

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Year:  2006        PMID： 17345745     DOI： 10.1039/b612197g

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  11 in total

1.  The flow synthesis of heterocycles for natural product and medicinal chemistry applications.

Authors:  Marcus Baumann; Ian R Baxendale; Steven V Ley
Journal:  Mol Divers       Date:  2010-10-20       Impact factor: 2.943

2.  Continuous flow based catch and release protocol for the synthesis of alpha-ketoesters.

Authors:  Alessandro Palmieri; Steven V Ley; Anastasios Polyzos; Mark Ladlow; Ian R Baxendale
Journal:  Beilstein J Org Chem       Date:  2009-05-20       Impact factor: 2.883

3.  Fully automated continuous flow synthesis of highly functionalized imidazo[1,2-a] heterocycles.

Authors:  Ananda Herath; Russell Dahl; Nicholas D P Cosford
Journal:  Org Lett       Date:  2010-02-05       Impact factor: 6.005

4.  Efficient amide bond formation through a rapid and strong activation of carboxylic acids in a microflow reactor.

Authors:  Shinichiro Fuse; Yuto Mifune; Takashi Takahashi
Journal:  Angew Chem Int Ed Engl       Date:  2013-12-02       Impact factor: 15.336

5.  Total synthesis of feglymycin based on a linear/convergent hybrid approach using micro-flow amide bond formation.

Authors:  Shinichiro Fuse; Yuto Mifune; Hiroyuki Nakamura; Hiroshi Tanaka
Journal:  Nat Commun       Date:  2016-11-28       Impact factor: 14.919

6.  Automated synthesis of prexasertib and derivatives enabled by continuous-flow solid-phase synthesis.

Authors:  Chenguang Liu; Jiaxun Xie; Wenbin Wu; Mu Wang; Weihao Chen; Shabana Binte Idres; Jiawei Rong; Lih-Wen Deng; Saif A Khan; Jie Wu
Journal:  Nat Chem       Date:  2021-04-19       Impact factor: 24.427

Review 7.  New approach in SARS-CoV-2 surveillance using biosensor technology: a review.

Authors:  Dina M El-Sherif; Mohamed Abouzid; Mohamed S Gaballah; Alhassan Ali Ahmed; Muhammad Adeel; Sheta M Sheta
Journal:  Environ Sci Pollut Res Int       Date:  2021-10-23       Impact factor: 4.223

8.  Synthesis of Natural and Unnatural Cyclooligomeric Depsipeptides Enabled by Flow Chemistry.

Authors:  Daniel Lücke; Toryn Dalton; Steven V Ley; Zoe E Wilson
Journal:  Chemistry       Date:  2016-02-04       Impact factor: 5.236

Review 9.  Flow Chemistry in Contemporary Chemical Sciences: A Real Variety of Its Applications.

Authors:  Marek Trojanowicz
Journal:  Molecules       Date:  2020-03-21       Impact factor: 4.411

10.  The Glutathione Metabolite γ-Glutamyl-Glutamate Partially Activates Glutamate NMDA Receptors in Central Neurons With Higher Efficacy for GluN2B-Containing Receptors.

Authors:  Fatiha Sebih; Nawfel Mokrane; Pierre Fontanel; Mete Kayatekin; Mahira Kaabeche; Janique Guiramand; Catherine Cohen-Solal; Thierry Cens; Matthieu Rousset; Pierre Charnet; Marie-Céleste De Jésus Ferreira; Jean-Baptiste Thibaud; Claudine Ménard; Sonia Cantel; Valérie Rolland; Michel Vignes; Julien Roussel
Journal:  Front Pharmacol       Date:  2022-01-03       Impact factor: 5.810
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