MOTIVATION: Epstein-Barr virus (EBV) infects greater than 90% of humans benignly for life but can be associated with tumors. It is a uniquely human pathogen that is amenable to quantitative analysis; however, there is no applicable animal model. Computer models may provide a virtual environment to perform experiments not possible in human volunteers. RESULTS: We report the application of a relatively simple stochastic cellular automaton (C-ImmSim) to the modeling of EBV infection. Infected B-cell dynamics in the acute and chronic phases of infection correspond well to clinical data including the establishment of a long term persistent infection (up to 10 years) that is absolutely dependent on access of latently infected B cells to the peripheral pool where they are not subject to immunosurveillance. In the absence of this compartment the infection is cleared. AVAILABILITY: The latest version 6 of C-ImmSim is available under the GNU General Public License and is downloadable from www.iac.cnr.it/~filippo/cimmsim.html
MOTIVATION: Epstein-Barr virus (EBV) infects greater than 90% of humans benignly for life but can be associated with tumors. It is a uniquely human pathogen that is amenable to quantitative analysis; however, there is no applicable animal model. Computer models may provide a virtual environment to perform experiments not possible in human volunteers. RESULTS: We report the application of a relatively simple stochastic cellular automaton (C-ImmSim) to the modeling of EBV infection. Infected B-cell dynamics in the acute and chronic phases of infection correspond well to clinical data including the establishment of a long term persistent infection (up to 10 years) that is absolutely dependent on access of latently infected B cells to the peripheral pool where they are not subject to immunosurveillance. In the absence of this compartment the infection is cleared. AVAILABILITY: The latest version 6 of C-ImmSim is available under the GNU General Public License and is downloadable from www.iac.cnr.it/~filippo/cimmsim.html
Authors: Vipin Narang; James Decraene; Shek-Yoon Wong; Bindu S Aiswarya; Andrew R Wasem; Shiang Rong Leong; Alexandre Gouaillard Journal: Immunol Res Date: 2012-09 Impact factor: 2.829
Authors: Henry H Balfour; Oludare A Odumade; David O Schmeling; Beth D Mullan; Julie A Ed; Jennifer A Knight; Heather E Vezina; William Thomas; Kristin A Hogquist Journal: J Infect Dis Date: 2012-10-24 Impact factor: 5.226
Authors: M Shapiro; K A Duca; K Lee; E Delgado-Eckert; J Hawkins; A S Jarrah; R Laubenbacher; N F Polys; V Hadinoto; D A Thorley-Lawson Journal: J Theor Biol Date: 2008-02-16 Impact factor: 2.691
Authors: Bernhard Pfeifer; Karl Kugler; Maria M Tejada; Christian Baumgartner; Michael Seger; Melanie Osl; Michael Netzer; Michael Handler; Andreas Dander; Manfred Wurz; Armin Graber; Bernhard Tilg Journal: Open Med Inform J Date: 2008-04-24