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Literature DB >> 18371986

A virtual look at Epstein-Barr virus infection: simulation mechanism.

M Shapiro¹, K A Duca, K Lee, E Delgado-Eckert, J Hawkins, A S Jarrah, R Laubenbacher, N F Polys, V Hadinoto, D A Thorley-Lawson.

Abstract

Epstein-Barr virus (EBV) is an important human pathogen that establishes a life-long persistent infection and for which no precise animal model exists. In this paper, we describe in detail an agent-based model and computer simulation of EBV infection. Agents representing EBV and sets of B and T lymphocytes move and interact on a three-dimensional grid approximating Waldeyer's ring, together with abstract compartments for lymph and blood. The simulation allows us to explore the development and resolution of virtual infections in a manner not possible in actual human experiments. Specifically, we identify parameters capable of inducing clearance, persistent infection, or death.

Entities: Disease Species

Mesh：

Year: 2008 PMID： 18371986 PMCID： PMC2515170 DOI： 10.1016/j.jtbi.2008.01.032

Source DB: PubMed Journal: J Theor Biol ISSN： 0022-5193 Impact factor: 2.691

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