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Literature DB >> 17339374

Artemisinins inhibit Trypanosoma cruzi and Trypanosoma brucei rhodesiense in vitro growth.

Yuliya V Mishina¹, Sanjeev Krishna, Richard K Haynes, John C Meade.

Abstract

Artemisinin compounds inhibit in vitro growth of cultured Trypanosoma cruzi and Trypanosoma brucei rhodesiense at concentrations in the low micromolar range. Artemisinin also inhibits calcium-dependent ATPase activity in T. cruzi membranes, suggesting a mode of action via membrane pumps. Artemisinins merit further investigation as chemotherapeutic options for these pathogens.

Entities: Chemical Species

Mesh：

Substances：

Year: 2007 PMID： 17339374 PMCID： PMC1855540 DOI： 10.1128/AAC.01544-06

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

23 in total

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Journal: Parasitology Date: 1993-01 Impact factor: 3.234

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