Literature DB >> 10354615

Artemisinin drugs in the treatment of malaria: from medicinal herb to registered medication.

M A van Agtmael1, T A Eggelte, C J van Boxtel.   

Abstract

Registration in Europe of several artemisinin drugs for the treatment of malaria can soon be expected. Artemisinin is isolated from the herb Artemisia annua, in use in China more than 2000 years as a herbal tea against fever. Artemisinin drugs are being used extensively in South-East Asia and increasingly in Africa. Active derivatives have been synthesized - artemether, arteether and artesunate - which are used for oral, intramuscular, rectal and intravenous administration. The origin, mechanism of action, efficacy and safety in patients, the pharmacokinetics and the position of this group of compounds among existing antimalarials are discussed in this review.

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Year:  1999        PMID： 10354615     DOI： 10.1016/s0165-6147(99)01302-4

Source DB:  PubMed          Journal:  Trends Pharmacol Sci        ISSN： 0165-6147            Impact factor:   14.819


  41 in total

Review 1.  Combination chemotherapy of schistosomiasis in laboratory studies and clinical trials.

Authors:  Jürg Utzinger; Jennifer Keiser; Xiao Shuhua; Marcel Tanner; Burton H Singer
Journal:  Antimicrob Agents Chemother       Date:  2003-05       Impact factor: 5.191

2.  Drug discovery from natural sources.

Authors:  Young-Won Chin; Marcy J Balunas; Hee Byung Chai; A Douglas Kinghorn
Journal:  AAPS J       Date:  2006-04-14       Impact factor: 4.009

Review 3.  Pregnane X receptor and natural products: beyond drug-drug interactions.

Authors:  Jeff L Staudinger; Xunshan Ding; Kristin Lichti
Journal:  Expert Opin Drug Metab Toxicol       Date:  2006-12       Impact factor: 4.481

4.  Artemisinins inhibit Trypanosoma cruzi and Trypanosoma brucei rhodesiense in vitro growth.

Authors:  Yuliya V Mishina; Sanjeev Krishna; Richard K Haynes; John C Meade
Journal:  Antimicrob Agents Chemother       Date:  2007-03-05       Impact factor: 5.191

5.  Role of dihydroartemisinin in regulating prostaglandin E2 synthesis cascade and inflammation in endothelial cells.

Authors:  Jie Yin; Weiwei Xia; Yue Zhang; Guixia Ding; Lihong Chen; Guangrui Yang; Songming Huang; Zhanjun Jia; Aihua Zhang
Journal:  Heart Vessels       Date:  2018-05-23       Impact factor: 2.037

6.  Semi-mechanistic pharmacokinetic/pharmacodynamic modelling of the antimalarial effect of artemisinin.

Authors:  Toufigh Gordi; Rujia Xie; William J Jusko
Journal:  Br J Clin Pharmacol       Date:  2005-12       Impact factor: 4.335

7.  The pharmacokinetic properties of intramuscular artesunate and rectal dihydroartemisinin in uncomplicated falciparum malaria.

Authors:  Kenneth F Ilett; Kevin T Batty; Shane M Powell; Tran Quang Binh; Le Thi Anh Thu; Hoang Lan Phuong; Nguyen Canh Hung; Timothy M E Davis
Journal:  Br J Clin Pharmacol       Date:  2002-01       Impact factor: 4.335

8.  Identification of two new trichome-specific promoters of Nicotiana tabacum.

Authors:  Mathieu Pottier; Raphaëlle Laterre; Astrid Van Wessem; Aldana M Ramirez; Xavier Herman; Marc Boutry; Charles Hachez
Journal:  Planta       Date:  2020-02-04       Impact factor: 4.116

9.  Cloning and functional characterization of a beta-pinene synthase from Artemisia annua that shows a circadian pattern of expression.

Authors:  Shan Lu; Ran Xu; Jun-Wei Jia; Jihai Pang; Seiichi P T Matsuda; Xiao-Ya Chen
Journal:  Plant Physiol       Date:  2002-09       Impact factor: 8.340

10.  Isolation, characterization and structural studies of amorpha - 4, 11-diene synthase (ADS(3963)) from Artemisia annua L.

Authors:  Pravej Alam; Usha Kiran; M Mobeen Ahmad; Mather Ali Khan; Shalu Jhanwar; Mz Abdin
Journal:  Bioinformation       Date:  2010-03-31
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