Literature DB >> 17333332

A randomized controlled trial of a decision aid for women considering genetic testing for breast and ovarian cancer risk.

Claire E Wakefield1, Bettina Meiser, Judi Homewood, Michelle Peate, Alan Taylor, Elizabeth Lobb, Judy Kirk, Mary-Anne Young, Rachel Williams, Tracy Dudding, Kathy Tucker.   

Abstract

PURPOSE: To measure the effectiveness of a tailored decision aid (DA) designed to help women make informed decisions about genetic testing for breast/ovarian cancer risk.
METHODS: A total of 145 women were randomized to receive the DA or a control pamphlet at the end of their first genetic counseling consultation. Of these, 120 (82.8%) completed two questionnaires, 1 week and 6 months post-consultation.
RESULTS: While the DA had no effect on informed choice, post-decisional regret or actual genetic testing decision, the trial showed that women who received the DA had higher knowledge levels and felt more informed about genetic testing than women who received the control pamphlet (chi(2)(2) = 6.82; P = 0.033; chi(2)(1) = 4.86; P = 0.028 respectively). The DA also helped women who did not have blood drawn at their first consultation to clarify their values with regards to genetic testing (chi(2)(1) = 5.27; P = 0.022). Women who received the DA were less likely to share the information with other family members than women in the control condition (chi(2)(1) = 8.78; P = 0.003).
CONCLUSIONS: Decision aids are an effective decision-support strategy for women considering genetic testing for breast/ovarian cancer risk, and are most effective before the patient has made a decision, which is generally at the point of having blood drawn.

Entities:  

Mesh:

Year:  2007        PMID: 17333332     DOI: 10.1007/s10549-007-9539-2

Source DB:  PubMed          Journal:  Breast Cancer Res Treat        ISSN: 0167-6806            Impact factor:   4.872


  26 in total

Review 1.  The importance and complexity of regret in the measurement of 'good' decisions: a systematic review and a content analysis of existing assessment instruments.

Authors:  Natalie Joseph-Williams; Adrian Edwards; Glyn Elwyn
Journal:  Health Expect       Date:  2010-09-23       Impact factor: 3.377

2.  An exploration of the communication preferences regarding genetic testing in individuals from families with identified breast/ovarian cancer mutations.

Authors:  Paboda Ratnayake; Claire E Wakefield; Bettina Meiser; Graeme Suthers; Melanie A Price; Jessica Duffy; Kathy Tucker
Journal:  Fam Cancer       Date:  2011-03       Impact factor: 2.375

3.  Assessment of psychosocial outcomes in genetic counseling research: an overview of available measurement scales.

Authors:  Nadine A Kasparian; Claire E Wakefield; Bettina Meiser
Journal:  J Genet Couns       Date:  2007-08-13       Impact factor: 2.537

4.  Development of Breast Cancer Choices: a decision support tool for young women with breast cancer deciding whether to have genetic testing for BRCA1/2 mutations.

Authors:  Chloe Grimmett; Charlotte Brooks; Alejandra Recio-Saucedo; Anne Armstrong; Ramsey I Cutress; D Gareth Evans; Ellen Copson; Lesley Turner; Bettina Meiser; Claire E Wakefield; Diana Eccles; Claire Foster
Journal:  Support Care Cancer       Date:  2018-06-28       Impact factor: 3.603

5.  A pre-visit tailored website enhances counselees' realistic expectations and knowledge and fulfils information needs for breast cancer genetic counselling.

Authors:  Akke Albada; Sandra van Dulmen; Dick Lindhout; Jozien M Bensing; Margreet G E M Ausems
Journal:  Fam Cancer       Date:  2012-03       Impact factor: 2.375

6.  Understanding Factors Associated with Uptake of BRCA1/2 Genetic Testing among Orthodox Jewish Women in the USA Using a Mixed-Methods Approach.

Authors:  Meghna S Trivedi; Hilary Colbeth; Haeseung Yi; Alejandro Vanegas; Rebecca Starck; Wendy K Chung; Paul S Appelbaum; Rita Kukafka; Isaac Schechter; Katherine D Crew
Journal:  Public Health Genomics       Date:  2019-06-04       Impact factor: 2.000

7.  Development of E-info gene(ca): a website providing computer-tailored information and question prompt prior to breast cancer genetic counseling.

Authors:  Akke Albada; Sandra van Dulmen; Roel Otten; Jozien M Bensing; Margreet G E M Ausems
Journal:  J Genet Couns       Date:  2009-05-14       Impact factor: 2.537

8.  Development of a fragile X syndrome (FXS) knowledge scale: towards a modified multidimensional measure of informed choice for FXS population carrier screening.

Authors:  Alice G Ames; Alice Jaques; Obioha C Ukoumunne; Alison D Archibald; Rony E Duncan; Jon Emery; Sylvia A Metcalfe
Journal:  Health Expect       Date:  2012-10-15       Impact factor: 3.377

9.  Randomized trial of a decision aid for BRCA1/BRCA2 mutation carriers: impact on measures of decision making and satisfaction.

Authors:  Marc D Schwartz; Heiddis B Valdimarsdottir; Tiffani A DeMarco; Beth N Peshkin; William Lawrence; Jessica Rispoli; Karen Brown; Claudine Isaacs; Suzanne O'Neill; Rebecca Shelby; Sherry C Grumet; Margaret M McGovern; Sarah Garnett; Heather Bremer; Suzanne Leaman; Kathryn O'Mara; Sarah Kelleher; Kathryn Komaridis
Journal:  Health Psychol       Date:  2009-01       Impact factor: 4.267

Review 10.  Genetic counselling and testing for inherited gene mutations in newly diagnosed patients with breast cancer: a review of the existing literature and a proposed research agenda.

Authors:  Bettina Meiser; Kathy Tucker; Michael Friedlander; Kristine Barlow-Stewart; Elizabeth Lobb; Christobel Saunders; Gillian Mitchell
Journal:  Breast Cancer Res       Date:  2008-11-28       Impact factor: 6.466

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