Literature DB >> 17327240

Development of a nanotechnology based low-LET multi-microbeam array single cell irradiation system.

S Chang1, J Zhang, D Bordelon, E Schreiber, A Cox, O Zhou.   

Abstract

A novel single cell irradiation system using carbon nanotube (CNT) based field emission technology is proposed. The system can produce electron microbeam at a large range of pulsation frequencies and dose rates with energy between 20 and 60 keV. Different from any existing single beam microbeam device, the CNT-based system can have 10,000 microbeam pixels, each is approximately 10 microm in size and individually controlled. Microscope imaging will be used for targeting cell(s) and the coordinate(s) identification. A single cell or large number of individually selected cells can be simultaneously irradiated under real time microscope observation. This poster reports our preliminary results in the initial stage of the CNT multipixel microbeam array development-prototype single pixel CNT microbeam device development.

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Year:  2007        PMID: 17327240     DOI: 10.1093/rpd/ncl508

Source DB:  PubMed          Journal:  Radiat Prot Dosimetry        ISSN: 0144-8420            Impact factor:   0.972


  4 in total

1.  An ultrasoft X-ray multi-microbeam irradiation system for studies of DNA damage responses by fixed- and live-cell fluorescence microscopy.

Authors:  Carel van Oven; Przemek M Krawczyk; Jan Stap; Arline M Melo; Maria H O Piazzetta; Angelo L Gobbi; Henk A van Veen; Jan Verhoeven; Jacob A Aten
Journal:  Eur Biophys J       Date:  2009-06-03       Impact factor: 1.733

2.  A carbon nanotube field emission multipixel x-ray array source for microradiotherapy application.

Authors:  Sigen Wang; Xiomara Calderon; Rui Peng; Eric C Schreiber; Otto Zhou; Sha Chang
Journal:  Appl Phys Lett       Date:  2011-05-25       Impact factor: 3.791

3.  Fabrication and Characterization of Individually Controlled Multi-Pixel Carbon Nanotube Cathode Array Chip for Micro-RT Application for Cancer Research.

Authors:  Sigen Wang; Zhijun Liu; Lei An; Otto Zhou; Sha Chang
Journal:  Mater Res Soc Symp Proc       Date:  2007-10-01

4.  Monte Carlo simulation of a compact microbeam radiotherapy system based on carbon nanotube field emission technology.

Authors:  Eric C Schreiber; Sha X Chang
Journal:  Med Phys       Date:  2012-08       Impact factor: 4.506

  4 in total

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