BACKGROUND: Surgical procedures and complications have rarely been described in patients receiving a third or subsequent renal transplant. METHODS: Data from 61 consecutive third (n=56), fourth (n=4), and fifth (n=1) renal transplants performed during 1974 to 2005 were analyzed retrospectively. RESULTS: Actuarial graft survival was 91%, 74%, and 57% at one, five, and 10 years, respectively. Technical failure accounted for the loss of three grafts (5%). A transperitoneal approach was necessary in 41% of patients. Technical difficulties occurred in half of the procedures, mainly due to atheroma or vascular calcifications. Overall, there were 45 surgical complications in 30 patients, of urological (n=11), vascular (n=6), infectious (n=9), hemorrhagic (n=12), digestive (n=3), or wound origin (n=4). The rate of surgical revision was 16%. Univariate analysis showed that among surgical complications, only vascular complications were associated with a poor graft outcome (P=0.02). Urological complications did not influence long-term graft outcome. Multivariate analysis of all surgical procedures and complications that might have influenced graft survival showed that only vascular complications were associated with a poorer graft outcome (relative risk=6.13, P=0.015). CONCLUSIONS: Despite a high rate of surgical complications and revisions, third and subsequent kidney transplantations may be performed safely by experienced surgeons without surgical complications influencing long-term graft outcome.
BACKGROUND: Surgical procedures and complications have rarely been described in patients receiving a third or subsequent renal transplant. METHODS: Data from 61 consecutive third (n=56), fourth (n=4), and fifth (n=1) renal transplants performed during 1974 to 2005 were analyzed retrospectively. RESULTS: Actuarial graft survival was 91%, 74%, and 57% at one, five, and 10 years, respectively. Technical failure accounted for the loss of three grafts (5%). A transperitoneal approach was necessary in 41% of patients. Technical difficulties occurred in half of the procedures, mainly due to atheroma or vascular calcifications. Overall, there were 45 surgical complications in 30 patients, of urological (n=11), vascular (n=6), infectious (n=9), hemorrhagic (n=12), digestive (n=3), or wound origin (n=4). The rate of surgical revision was 16%. Univariate analysis showed that among surgical complications, only vascular complications were associated with a poor graft outcome (P=0.02). Urological complications did not influence long-term graft outcome. Multivariate analysis of all surgical procedures and complications that might have influenced graft survival showed that only vascular complications were associated with a poorer graft outcome (relative risk=6.13, P=0.015). CONCLUSIONS: Despite a high rate of surgical complications and revisions, third and subsequent kidney transplantations may be performed safely by experienced surgeons without surgical complications influencing long-term graft outcome.
Authors: Vital Hevia; Victoria Gómez; Manuel Hevia; Javier Lorca; Marta Santiago; Ana Dominguez; Sara Álvarez; Víctor Díez; Cristina Gordaliza; Francisco Javier Burgos Journal: Curr Urol Rep Date: 2020-02-04 Impact factor: 3.092
Authors: Lampros Kousoulas; Florian W R Vondran; Paulina Syryca; Juergen Klempnauer; Harald Schrem; Frank Lehner Journal: J Transplant Date: 2015-02-01
Authors: Shaifali Sandal; JiYoon B Ahn; Dorry L Segev; Marcelo Cantarovich; Mara A McAdams-DeMarco Journal: Am J Transplant Date: 2021-08-23 Impact factor: 8.086