BACKGROUND: Cardiac power output (CPO) is a novel hemodynamic measurement that represents cardiac pumping ability. The prognostic value of CPO in a broad spectrum of patients with acute cardiac disease undergoing pulmonary artery catheterization (PAC) has not been examined. METHODS: Consecutive patients with a primary cardiac diagnosis who were undergoing PAC in a single coronary care unit were included. The relationship between initial CPO [(mean arterial pressure x cardiac output [CO])/451] and inhospital mortality was evaluated. CPO was analyzed both as a dichotomous variable (using a cutoff value previously established among patients with cardiogenic shock) and as a continuous variable. RESULTS: Data were available for 349 patients. The mean CPO was 0.88 +/- 0.37 W. The inhospital mortality rate was significantly higher among patients with a CPO < or = 0.53 W (n = 53) compared with those with a CPO > 0.53 W (n = 296) (49% vs 20%, P < .001). In separate multivariate analyses, both CPO and CO were associated with inhospital mortality. However, when both terms were included simultaneously, CPO remained strongly associated with mortality (odds ratio 0.63, 95% CI 0.43-0.91, P = .01), whereas CO did not (odds ratio 1.05, 95% CI 0.75-1.48, P = .78). CONCLUSIONS: Cardiac power output is a strong, independent predictor of inhospital mortality in a broad spectrum of patients with primary cardiac disease undergoing PAC.
BACKGROUND: Cardiac power output (CPO) is a novel hemodynamic measurement that represents cardiac pumping ability. The prognostic value of CPO in a broad spectrum of patients with acute cardiac disease undergoing pulmonary artery catheterization (PAC) has not been examined. METHODS: Consecutive patients with a primary cardiac diagnosis who were undergoing PAC in a single coronary care unit were included. The relationship between initial CPO [(mean arterial pressure x cardiac output [CO])/451] and inhospital mortality was evaluated. CPO was analyzed both as a dichotomous variable (using a cutoff value previously established among patients with cardiogenic shock) and as a continuous variable. RESULTS: Data were available for 349 patients. The mean CPO was 0.88 +/- 0.37 W. The inhospital mortality rate was significantly higher among patients with a CPO < or = 0.53 W (n = 53) compared with those with a CPO > 0.53 W (n = 296) (49% vs 20%, P < .001). In separate multivariate analyses, both CPO and CO were associated with inhospital mortality. However, when both terms were included simultaneously, CPO remained strongly associated with mortality (odds ratio 0.63, 95% CI 0.43-0.91, P = .01), whereas CO did not (odds ratio 1.05, 95% CI 0.75-1.48, P = .78). CONCLUSIONS: Cardiac power output is a strong, independent predictor of inhospital mortality in a broad spectrum of patients with primary cardiac disease undergoing PAC.
Authors: Matthew Coutsos; Javier A Sala-Mercado; Masashi Ichinose; Zhenhua Li; Elizabeth J Dawe; Donal S O'Leary Journal: J Appl Physiol (1985) Date: 2010-04-22
Authors: Kapil Gupta; Soren Sondergaard; Geoffrey Parkin; Mark Leaning; Anders Aneman Journal: Intensive Care Med Date: 2015-01-08 Impact factor: 17.440
Authors: Alexander G Truesdell; Behnam Tehrani; Ramesh Singh; Shashank Desai; Patricia Saulino; Scott Barnett; Stephen Lavanier; Charles Murphy Journal: Interv Cardiol Date: 2018-05
Authors: Karl Werdan; Martin Ruß; Michael Buerke; Georg Delle-Karth; Alexander Geppert; Friedrich A Schöndube Journal: Dtsch Arztebl Int Date: 2012-05-11 Impact factor: 5.594
Authors: Matthew Coutsos; Javier A Sala-Mercado; Masashi Ichinose; Zhenhua Li; Elizabeth J Dawe; Donal S O'Leary Journal: Am J Physiol Heart Circ Physiol Date: 2013-01-25 Impact factor: 4.733