| Literature DB >> 1729690 |
R Zwanzig1, A Szabo, B Bagchi.
Abstract
Levinthal's paradox is that finding the native folded state of a protein by a random search among all possible configurations can take an enormously long time. Yet proteins can fold in seconds or less. Mathematical analysis of a simple model shows that a small and physically reasonable energy bias against locally unfavorable configurations, of the order of a few kT, can reduce Levinthal's time to a biologically significant size.Mesh：
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Year: 1992 PMID： 1729690 PMCID： PMC48166 DOI： 10.1073/pnas.89.1.20
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205