Literature DB >> 16182447

Regulation of serine racemase activity by D-serine and nitric oxide in human glioblastoma cells.

Kazuo Shoji1, Sofia Mariotto, Anna Rosa Ciampa, Hisanori Suzuki.   

Abstract

In the human glioblastoma cell line U87, the activity of serine racemase (SR), catalyzing the isomerisation of serine, was inversely regulated by D-serine and nitric oxide (NO), a neuromodulator and a neurotransmitter, respectively. SR activity was dose-dependently enhanced up to five times in cells treated with 10 mM D-serine, whereas it was inhibited by NO. Furthermore, D-serine was found to induce the denitrosylation of SR purified from mouse brain. These results suggest that serine racemase activity in astrocyte is regulated inversely by d-serine and NO. SR should be inhibited through nitrosylation by NO and activated through denitrosylation elicited by D-serine.

Entities:  

Mesh：

Substances：

Year:  2005        PMID： 16182447     DOI： 10.1016/j.neulet.2005.08.063

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  13 in total

1.  Meta-analysis of the efficacy of adjunctive NMDA receptor modulators in chronic schizophrenia.

Authors:  Surendra P Singh; Vidhi Singh
Journal:  CNS Drugs       Date:  2011-10-01       Impact factor: 5.749

Review 2.  Glutamate receptor ion channels: structure, regulation, and function.

Authors:  Stephen F Traynelis; Lonnie P Wollmuth; Chris J McBain; Frank S Menniti; Katie M Vance; Kevin K Ogden; Kasper B Hansen; Hongjie Yuan; Scott J Myers; Ray Dingledine
Journal:  Pharmacol Rev       Date:  2010-09       Impact factor: 25.468

Review 3.  Neuropathogenesis of HIV-1-associated neurocognitive disorders: a possible involvement of D-serine.

Authors:  Jianxun Xia; Huangui Xiong
Journal:  Int J Physiol Pathophysiol Pharmacol       Date:  2013-09-10

4.  Human serine racemase structure/activity relationship studies provide mechanistic insight and point to position 84 as a hot spot for β-elimination function.

Authors:  David L Nelson; Greg A Applegate; Matthew L Beio; Danielle L Graham; David B Berkowitz
Journal:  J Biol Chem       Date:  2017-07-10       Impact factor: 5.157

Review 5.  Metabolism of the neuromodulator D-serine.

Authors:  Loredano Pollegioni; Silvia Sacchi
Journal:  Cell Mol Life Sci       Date:  2010-03-02       Impact factor: 9.261

6.  Nitric oxide S-nitrosylates serine racemase, mediating feedback inhibition of D-serine formation.

Authors:  Asif K Mustafa; Manish Kumar; Balakrishnan Selvakumar; Gary P H Ho; Jeffrey T Ehmsen; Roxanne K Barrow; L Mario Amzel; Solomon H Snyder
Journal:  Proc Natl Acad Sci U S A       Date:  2007-02-09       Impact factor: 11.205

7.  Roles of quaternary structure and cysteine residues in the activity of human serine racemase.

Authors:  Wei Wang; Steven W Barger
Journal:  BMC Biochem       Date:  2011-12-08       Impact factor: 4.059

Review 8.  D-serine signalling as a prominent determinant of neuronal-glial dialogue in the healthy and diseased brain.

Authors:  J-M Billard
Journal:  J Cell Mol Med       Date:  2008-03-20       Impact factor: 5.310

9.  D-Serine metabolism in C6 glioma cells: Involvement of alanine-serine-cysteine transporter (ASCT2) and serine racemase (SRR) but not D-amino acid oxidase (DAO).

Authors:  Pilleriin Sikka; Rosie Walker; Rebecca Cockayne; Matthew J A Wood; Paul J Harrison; Philip W J Burnet
Journal:  J Neurosci Res       Date:  2010-06       Impact factor: 4.164

Review 10.  Glutamatergic Mechanisms in Glioblastoma and Tumor-Associated Epilepsy.

Authors:  Falko Lange; Julia Hörnschemeyer; Timo Kirschstein
Journal:  Cells       Date:  2021-05-17       Impact factor: 6.600
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.