| Literature DB >> 17276395 |
Motonobu Osada1, Hannah Lui Park, Min Joo Park, Jun-Wei Liu, Guojun Wu, Barry Trink, David Sidransky.
Abstract
GDF15 is a transcriptional target gene for p53 and its family members, p63 and p73. Its promoter region contains two p53-type response elements, RE1 and RE2, and RE2 confers p53-specific transactivation. RE2 contains several mismatches from the canonical p53 response element (RRRCWWGYYY). Two mismatches in the RRR span and T base of the RE2 core sequence in the most 3' quarter-site are critical for inhibiting the binding affinity to p63 and p73 and corresponding promoter activity. Our results strongly suggest that differential DNA-binding affinities between p53 family member proteins act, at least in part, to confer specific target gene activation.Entities:
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Year: 2007 PMID： 17276395 PMCID： PMC1975780 DOI： 10.1016/j.bbrc.2007.01.089
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575