BACKGROUND AND PURPOSE: This review characterizes the current state of knowledge of high-density lipoprotein (HDL) in relation to stroke. SUMMARY OF REVIEW: HDL has anti-atherosclerotic and anti-inflammatory properties and is an important component in atherosclerosis. Serum HDL-cholesterol levels are inversely related to heart disease and stroke risk. There are various established and experimental treatments which can raise serum HDL cholesterol and improve its function. CONCLUSIONS: HDL is an emerging target for atherosclerotic stroke treatment with the potential to dramatically impact the care of stroke patients.
BACKGROUND AND PURPOSE: This review characterizes the current state of knowledge of high-density lipoprotein (HDL) in relation to stroke. SUMMARY OF REVIEW: HDL has anti-atherosclerotic and anti-inflammatory properties and is an important component in atherosclerosis. Serum HDL-cholesterol levels are inversely related to heart disease and stroke risk. There are various established and experimental treatments which can raise serum HDL cholesterol and improve its function. CONCLUSIONS: HDL is an emerging target for atherosclerotic stroke treatment with the potential to dramatically impact the care of strokepatients.
Authors: Frank M Sacks; Lawrence L Rudel; Adam Conner; Hassibullah Akeefe; Gerhard Kostner; Talal Baki; George Rothblat; Margarita de la Llera-Moya; Bela Asztalos; Timothy Perlman; Chunyu Zheng; Petar Alaupovic; Jo-Ann B Maltais; H Bryan Brewer Journal: J Lipid Res Date: 2009-01-14 Impact factor: 5.922
Authors: Anna Murray; Christie Cluett; Stefania Bandinelli; Anna Maria Corsi; Luigi Ferrucci; Jack Guralnik; Andrew Singleton; Timothy Frayling; David Melzer Journal: Eur Heart J Date: 2009-05-12 Impact factor: 29.983
Authors: Casandra M Cartagena; Farid Ahmed; Mark P Burns; Ahdeah Pajoohesh-Ganji; Daniel T Pak; Alan I Faden; G William Rebeck Journal: J Neurotrauma Date: 2008-09 Impact factor: 5.269