OBJECTIVE: Our objective was to evaluate the prognostic value of baseline plasma RANTES levels in patients with known or suspected coronary artery disease. RANTES is a chemokine produced by a variety of cell types including platelets that has been implicated in atherosclerosis. METHODS AND RESULTS: Baseline plasma RANTES levels were measured in 389 male patients undergoing coronary angiography at a Veterans Affairs Medical Center. The patients were followed-up prospectively for the occurrence of cardiac mortality and myocardial infarction. Follow-up data at 24 months were available for 97% of patients. In the entire cohort of patients, low baseline RANTES levels were an independent predictor of cardiac mortality. For cardiac death at 24 months, the survival rate was 87.3% in the lowest tertile of RANTES values, compared with 94% in the upper 2 tertiles combined (P=0.0298 by log rank test). Furthermore, when patients were risk-stratified into those with and without an acute coronary syndrome, RANTES was an independent predictor of both cardiac mortality and myocardial infarction in those without an acute coronary syndrome. Finally, RANTES was also an independent predictor of cardiac mortality in the diabetic subset. CONCLUSIONS: In a cohort of male patients undergoing coronary angiography, low baseline plasma RANTES levels are an independent predictor of cardiac mortality.
OBJECTIVE: Our objective was to evaluate the prognostic value of baseline plasma RANTES levels in patients with known or suspected coronary artery disease. RANTES is a chemokine produced by a variety of cell types including platelets that has been implicated in atherosclerosis. METHODS AND RESULTS: Baseline plasma RANTES levels were measured in 389 male patients undergoing coronary angiography at a Veterans Affairs Medical Center. The patients were followed-up prospectively for the occurrence of cardiac mortality and myocardial infarction. Follow-up data at 24 months were available for 97% of patients. In the entire cohort of patients, low baseline RANTES levels were an independent predictor of cardiac mortality. For cardiac death at 24 months, the survival rate was 87.3% in the lowest tertile of RANTES values, compared with 94% in the upper 2 tertiles combined (P=0.0298 by log rank test). Furthermore, when patients were risk-stratified into those with and without an acute coronary syndrome, RANTES was an independent predictor of both cardiac mortality and myocardial infarction in those without an acute coronary syndrome. Finally, RANTES was also an independent predictor of cardiac mortality in the diabetic subset. CONCLUSIONS: In a cohort of male patients undergoing coronary angiography, low baseline plasma RANTES levels are an independent predictor of cardiac mortality.
Authors: Katarzyna Korybalska; Małgorzata Pyda; Stefan Grajek; Magdalena Lanocha; Andrzej Breborowicz; Janusz Witowski Journal: Clin Res Cardiol Date: 2010-02-07 Impact factor: 5.460
Authors: Nasimudeen R Jabir; Chelapram K Firoz; Mohammad A Kamal; Ghazi A Damanhouri; Mohammed Nabil Alama; Anas S Alzahrani; Hussein A Almehdar; Shams Tabrez Journal: J Clin Lab Anal Date: 2016-11-09 Impact factor: 2.352
Authors: Salim S Virani; Vijay Nambi; Ron Hoogeveen; Bruce A Wasserman; Josef Coresh; Franklyn Gonzalez; Lloyd E Chambless; Thomas H Mosley; Eric Boerwinkle; Christie M Ballantyne Journal: Eur Heart J Date: 2010-10-12 Impact factor: 29.983
Authors: J Podolec; G Kopec; L Niewiara; M Komar; B Guzik; K Bartus; L Tomkiewicz-Pajak; T J Guzik; W Plazak; K Zmudka Journal: J Physiol Pharmacol Date: 2016-04 Impact factor: 3.011