BACKGROUND: Monocyte chemoattractant protein-1 (MCP-1) plays a key role in the pathogenesis of atherosclerosis and has been proposed as a biomarker for patients with cardiovascular disease. METHODS: To assess its clinical usefulness, serum MCP-1 concentrations were measured in patients with ST-elevation myocardial infarction (MI) at admission, immediately after percutaneous coronary intervention (PCI), at 24 h, and after 6 months. RESULTS: We found no differences in MCP-1 concentrations between patients with acute MI, patients with stable coronary artery disease and healthy individuals. Although median MCP-1 concentrations in patients with MI were similar at admission and after 6 months, there were significant differences between individuals in how MCP-1 levels changed with time. As demonstrated by comparing baseline quartiles of MCP-1, the levels of MCP-1 tended to increase in patients with low MCP-1 concentration at admission, and decrease in patients with initially high MCP-1 levels. We found an inverse correlation between MCP-1 concentration at baseline and the time to reperfusion, and detected a significant decrease in MCP-1 concentration immediately after PCI. We also observed lower MCP-1 concentrations over time in patients who developed restenosis within 6 months. However, we did not confirm the association between MCP-1 concentrations at baseline and a number of previously implicated demographic, clinical and laboratory criteria. CONCLUSIONS: Our data demonstrate some new aspects of MCP-1 measurement in patients with MI, but do not corroborate many earlier observations.
BACKGROUND:Monocyte chemoattractant protein-1 (MCP-1) plays a key role in the pathogenesis of atherosclerosis and has been proposed as a biomarker for patients with cardiovascular disease. METHODS: To assess its clinical usefulness, serum MCP-1 concentrations were measured in patients with ST-elevation myocardial infarction (MI) at admission, immediately after percutaneous coronary intervention (PCI), at 24 h, and after 6 months. RESULTS: We found no differences in MCP-1 concentrations between patients with acute MI, patients with stable coronary artery disease and healthy individuals. Although median MCP-1 concentrations in patients with MI were similar at admission and after 6 months, there were significant differences between individuals in how MCP-1 levels changed with time. As demonstrated by comparing baseline quartiles of MCP-1, the levels of MCP-1 tended to increase in patients with low MCP-1 concentration at admission, and decrease in patients with initially high MCP-1 levels. We found an inverse correlation between MCP-1 concentration at baseline and the time to reperfusion, and detected a significant decrease in MCP-1 concentration immediately after PCI. We also observed lower MCP-1 concentrations over time in patients who developed restenosis within 6 months. However, we did not confirm the association between MCP-1 concentrations at baseline and a number of previously implicated demographic, clinical and laboratory criteria. CONCLUSIONS: Our data demonstrate some new aspects of MCP-1 measurement in patients with MI, but do not corroborate many earlier observations.
Authors: F Cipollone; M Marini; M Fazia; B Pini; A Iezzi; M Reale; L Paloscia; G Materazzo; E D'Annunzio; P Conti; F Chiarelli; F Cuccurullo; A Mezzetti Journal: Arterioscler Thromb Vasc Biol Date: 2001-03 Impact factor: 8.311
Authors: Małgorzata Pyda; Katarzyna Korybalska; Krzysztof Ksiazek; Stefan Grajek; Magdalena Lanocha; Maciej Lesiak; Justyna Wiśniewska-Elnur; Anna Olasińska; Andrzej Breborowicz; Andrzej Cieśliński; Janusz Witowski Journal: Am J Cardiol Date: 2006-08-07 Impact factor: 2.778
Authors: Ron C Hoogeveen; Alanna Morrison; Eric Boerwinkle; J Shawn Miles; Charles E Rhodes; A Richey Sharrett; Christie M Ballantyne Journal: Atherosclerosis Date: 2005-04-14 Impact factor: 5.162
Authors: James A de Lemos; David A Morrow; Michael A Blazing; Petr Jarolim; Stephen D Wiviott; Marc S Sabatine; Robert M Califf; Eugene Braunwald Journal: J Am Coll Cardiol Date: 2007-11-13 Impact factor: 24.094
Authors: Anders Gabrielsen; Patrick R Lawler; Wang Yongzhong; Daniel Steinbrüchel; Dimo Blagoja; Gabrielle Paulsson-Berne; Jens Kastrup; Göran K Hansson Journal: J Mol Cell Cardiol Date: 2007-01-08 Impact factor: 5.000
Authors: Eva S Kehmeier; Wolfgang Lepper; Martina Kropp; Christian Heiss; Ulrike Hendgen-Cotta; Jan Balzer; Mirja Neizel; Christian Meyer; Marc W Merx; Pablo E Verde; Christian Ohmann; Gerd Heusch; Malte Kelm; Tienush Rassaf Journal: Clin Res Cardiol Date: 2012-05-06 Impact factor: 5.460