| Literature DB >> 17254958 |
Adam Friedman1, Norbert Perrimon.
Abstract
In contrast to animal-based mutant phenotype assays, recent biochemical and quantitative genetic studies have identified hundreds of potential regulators of known signaling pathways. We discuss the discrepancy between previous models and new data, put forward a different signaling conceptual framework incorporating time-dependent quantitative contributions, and suggest how this new framework can impact our study of human disease.Entities:
Mesh：
Year: 2007 PMID： 17254958 DOI： 10.1016/j.cell.2007.01.007
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582